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首页> 外文期刊>Psychiatry Research. Neuroimaging >Using short-range and long-range functional connectivity to identify schizophrenia with a family-based case-control design
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Using short-range and long-range functional connectivity to identify schizophrenia with a family-based case-control design

机译：使用短距离和远程功能连通性，以识别具有基于家庭的案例控制设计的精神分裂症

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摘要

Abnormal short-range and long-range functional connectivities (FCs) have been implicated in the neurophysiology of schizophrenia. This study was conducted to examine the potential of short-range and long-range FCs for differentiating the patients from the controls with a family-based case-control design. Twenty-eight first-episode, drug-naive patients with schizophrenia, 28 unaffected siblings of the patients (family-based controls, FBCs), and 40 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (fMRI) scans. The data were analyzed by short-range and long-range FC analyses, receiver operating characteristic curve (ROC) and support vector machine (SVM). Compared with the FBCs/HCs, the patients exhibit increased short-range positive FC strength (spFCS) and/or long-range positive FC strength (lpFCS) in the default-mode network (DMN) and decreased spFCS and lpFCS in the sensorimotor circuits. Furthermore, a combination of the spFCS values in the right superior parietal lobule and the lpFCS values in the left fusiform gyrus/cerebellum VI can differentiate the patients from the FBCs with high sensitivity and specificity. The findings highlight the importance of the DMN and sensorimotor circuits in the pathogenesis of schizophrenia. Combining with family-based case-control design may be a viable option to limit the confounding effects of environmental risk factors in neuroimaging studies of schizophrenia.
机译：异常的短程和长程功能性连接性（FCs）与精神分裂症的神经生理学有关。本研究旨在通过基于家庭的病例对照设计，检验短程和远程FCs在区分患者与对照组方面的潜力。28名首次发作、未服用药物的精神分裂症患者、28名未受影响的患者兄弟姐妹（基于家庭的对照组，FBC）和40名健康对照组（HCs）接受静息状态功能磁共振成像（fMRI）扫描。通过短程和长程FC分析、接收机工作特性曲线（ROC）和支持向量机（SVM）对数据进行分析。与FBC/HCs相比，患者在默认模式网络（DMN）中的短程正FC强度（SPFC）和/或长程正FC强度（LPFC）增加，在感觉运动回路中的SPFC和LPFC减少。此外，结合右侧顶上小叶的SPFC值和左侧梭状回/小脑VI的LPFC值，可以以高度的敏感性和特异性将患者与FBC区分开来。这些发现强调了DMN和感觉运动回路在精神分裂症发病机制中的重要性。结合基于家庭的病例对照设计可能是限制精神分裂症神经影像学研究中环境危险因素混杂效应的可行选择。

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