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首页> 外文期刊>Psychiatry Research. Neuroimaging >Dendrite complexity of the posterior cingulate cortex as a substrate for recovery from post-stroke depression: A pilot study
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Dendrite complexity of the posterior cingulate cortex as a substrate for recovery from post-stroke depression: A pilot study

机译：后刺刺刺伤皮质的枝晶复杂性作为卒中后抑郁症的底物：试验研究

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The neural basis of recovery from a depressive state remains poorly understood. The main purpose of this study was to determine the neural basis of vulnerability/resilience to depression in stroke patients in terms of changes in regional microstructure. The study included 20 individuals with acute ischaemic stroke. Symptoms of depression were assessed, and the intraneurite volume fraction and neurite orientation-dispersion index (ODI) were evaluated by a multi-shell diffusion imaging and neurite-orientation dispersion and density imaging model. Patients underwent follow-up examinations after 2 months and were classified into depression improvement and depression deterioration groups. A significant interaction effect of group x time on the ODI was shown by voxel-based analysis in the posterior cingulate cortex (PCC). The ODI change in the PCC was negatively correlated with the change in the depression scale scores at the 2-month time point. The increase in ODI in the PCC that occurred during the 2-month interval was thought to be associated with decreased depressive symptom scores. As the ODI represents the pattern of sprawling dendrite progression, our findings indicate that the dendritic complexity of the PCC is a substrate for recovery in individuals who experienced post-stroke psychosocial and biological stress.
机译：从抑郁状态中恢复的神经基础仍然知之甚少。本研究的主要目的是根据脑卒中患者局部微观结构的变化，确定其抑郁脆弱性/恢复力的神经基础。这项研究包括20名急性缺血性中风患者。采用多壳层扩散成像和轴突定向弥散及密度成像模型评估抑郁症状，并评估神经内体积分数和轴突定向弥散指数（ODI）。患者在2个月后接受随访检查，分为抑郁改善组和抑郁恶化组。基于体素的后扣带回皮质（PCC）分析显示，x组时间对ODI有显著的交互作用。在2个月的时间点，PCC的ODI变化与抑郁量表得分的变化呈负相关。在2个月的时间间隔内，PCC的ODI增加被认为与抑郁症状评分降低有关。由于ODI代表了树突扩展的模式，我们的研究结果表明，PCC的树突复杂性是经历卒中后心理社会和生物应激的个体恢复的基础。

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