• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >A multivariate analysis of the association between corticostriatal functional connectivity and psychosis-like experiences in the general community
【24h】

A multivariate analysis of the association between corticostriatal functional connectivity and psychosis-like experiences in the general community

机译：一种多变量分析普通社区皮质血管功能连通性与精神病的关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dysfunction of dorsal corticostriatal (CST) circuitry is thought to play an important role in psychosis. Here, we use multivariate analysis to characterize covariance between CST functional connectivity and psychosis-like experiences (PLEs) in non-clinical individuals. In 353 healthy adults (155 males), we use partial least squares (PLS) to identify latent variables (LV) describing covariance between seven PLE questionnaire measures and functional connectivity estimated between each of six striatal seed regions and the rest of the brain using multiband resting-state fMRI. Hypothesis-driven PLS of the dorsal caudate (DC) seed identified one significant LV, accounting for 23.88% of covariance, with loadings from nearly all PLE subscales. Cortical regions implicated in this LV comprise anterior cingulate and left dorsolateral prefrontal cortex. Lower connectivity between these cortical areas and the DC seed was associated with more severe PLEs. Using multivariate modeling, we identified an association between dorsal CST connectivity and PLEs in the general community that implicates similar brain regions to those identified in patient groups. Our results highlight that the severity of both positive/negative symptom-like PLEs is related with functional coupling between the DC and dorsolateral PFC, suggesting this neural circuit may play a role in mediating risk for general psychosis-related psychopathology.
机译：背侧皮质介体（CST）回路的功能障碍被认为在精神病中起重要作用。在这里，我们使用多变量分析来描述非临床个体CST功能连通性和精神病样体验（PLEs）之间的协方差。在353名健康成人（155名男性）中，我们使用偏最小二乘法（PLS）来识别潜在变量（LV），这些变量描述了七个PLE问卷测量值之间的协方差，以及使用多波段静息状态功能磁共振成像估计的六个纹状体种子区和大脑其余部分之间的功能连通性。背尾状核（DC）种子的假设驱动PLS确定了一个显著的LV，占协方差的23.88%，几乎所有PLE分量表都有负荷。左室涉及的皮质区域包括前扣带回和左背外侧前额叶皮质。这些皮质区域与DC种子之间的低连通性与更严重的PLEs相关。使用多变量建模，我们确定了一般社区中背侧CST连通性和PLEs之间的关联，该关联涉及与患者组中确定的相似的大脑区域。我们的结果强调，阳性/阴性症状（如PLEs）的严重程度与DC和背外侧PFC之间的功能耦合有关，表明该神经回路可能在介导一般精神病相关精神病理学的风险中发挥作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号