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首页> 外文期刊>Psychiatry Research. Neuroimaging >Neural activation in stress-related exhaustion: Cross-sectional observations and interventional effects
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Neural activation in stress-related exhaustion: Cross-sectional observations and interventional effects

机译：在应力相关耗尽中的神经激活：横截面观察和介入效应

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Abstract The primary purpose of this study was to investigate the association between burnout and neural activation during working memory processing in patients with stress-related exhaustion. Additionally, we investigated the neural effects of cognitive training as part of stress rehabilitation. Fifty-five patients with clinical diagnosis of exhaustion disorder were administered the n -back task during fMRI scanning at baseline. Ten patients completed a 12-week cognitive training intervention, as an addition to stress rehabilitation. Eleven patients served as a treatment-as-usual control group. At baseline, burnout level was positively associated with neural activation in the rostral prefrontal cortex, the posterior parietal cortex and the striatum, primarily in the 2-back condition. Following stress rehabilitation, the striatal activity decreased as a function of improved levels of burnout. No significant association between burnout level and working memory performance was found, however, our findings indicate that frontostriatal neural responses related to working memory were modulated by burnout severity. We suggest that patients with high levels of burnout need to recruit additional cognitive resources to uphold task performance. Following cognitive training, increased neural activation was observed during 3-back in working memory-related regions, including the striatum, however, low sample size limits any firm conclusions. Highlights ? Frontostriatal circuits are affected in patients with exhaustion disorder. ? Patients high in burnout recruit additional neural resources to uphold task performance. ? This compensatory mechanism may partly explain patients' reports of mental fatigue. ? Neural function may be modified with treatment in this patient group. ? Cognitive training may be a useful addition to stress rehabilitation.
机译：摘要本研究的主要目的是探讨压力相关疲劳患者在工作记忆处理过程中的倦怠与神经激活之间的关系。此外，我们还研究了作为应激康复一部分的认知训练的神经效应。55名临床诊断为疲劳障碍的患者在基线进行功能磁共振扫描时接受了n-back任务。10名患者完成了为期12周的认知训练干预，作为压力康复的补充。11名患者作为常规对照组进行治疗。在基线检查时，倦怠水平与嘴侧前额叶皮质、后顶叶皮质和纹状体的神经激活呈正相关，主要是在2-back状态下。应激康复后，纹状体活性随着倦怠水平的提高而降低。然而，我们的研究结果表明，与工作记忆相关的额叶皮层神经反应受工作倦怠严重程度的调节。我们建议，高度倦怠的患者需要招募额外的认知资源来维持任务绩效。认知训练后，在工作记忆相关区域（包括纹状体）的3-back过程中观察到神经激活增加，然而，低样本量限制了任何确定的结论。亮点？疲惫障碍患者的额叶纹状体回路受到影响？精疲力竭的患者会招募额外的神经资源来维持任务绩效？这种代偿机制可以部分解释患者精神疲劳的报告？这组患者的神经功能可以通过治疗得到改善？认知训练可能是压力康复的有益补充。

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