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首页> 外文期刊>Psychiatry Research. Neuroimaging >White Matter Integrity According to the Stage of Mental Disorder in Youth
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White Matter Integrity According to the Stage of Mental Disorder in Youth

机译：白质诚信根据青年精神障碍的阶段

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摘要

The present study investigated differences in white matter (WM) integrity between 96 young people with affective and/or psychotic symptoms classified at an early stage of mental disorder (i.e. 'attenuated syndrome'; stage 1b), 85 young people classified at a more advanced stage of mental disorder (i.e. 'discrete disorder'; stage 2), and 81 demographically matched healthy controls using diffusion tensor imaging. The relationship between WM integrity (indexed by fractional anisotropy; FA) across the tracts and neuropsychological functioning was also investigated. A significant reduction in FA was identified in those with more advanced disorder in the body of the corpus callosum. Clinical stage groups were associated with significant neuropsychological impairment, which was significantly greater in those with discrete disorders. Compared to those in the earlier stage of disorder, participants at the later clinical stage showed decreased FA in the body of the corpus callosum that was associated with worse performance in attentional set formation maintenance, shifting and flexibility. These results provide further support for clinical staging of mental disorder and highlight the potential for utilising neuroanatomical biomarkers to support the classification of stages of mental disorder in the future.
机译：本研究调查了96名患有情感和/或精神病性症状的年轻人在精神障碍早期（即“减弱综合征”；1b期）和85名精神障碍晚期（即“离散性障碍”；2期）之间的白质完整性差异，81名人口统计学匹配的健康对照组使用扩散张量成像。此外，还研究了跨束的WM完整性（由分数各向异性指数；FA）与神经心理功能之间的关系。在胼胝体更严重的疾病患者中，FA显著降低。临床阶段组与显著的神经心理损伤相关，而离散性疾病组的神经心理损伤显著更大。与疾病早期的参与者相比，临床后期的参与者表现出胼胝体中FA的减少，这与注意力集形成的维持、转移和灵活性的表现较差有关。这些结果为精神障碍的临床分期提供了进一步的支持，并强调了未来利用神经解剖学生物标记物支持精神障碍分期的潜力。

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