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首页> 外文期刊>Psychiatry Research. Neuroimaging >Sex hormones partially explain the sex-dependent effect of lifetime alcohol use on adolescent white matter microstructure
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Sex hormones partially explain the sex-dependent effect of lifetime alcohol use on adolescent white matter microstructure

机译：性激素部分解释了寿命醇类在青少年白质微观结构上的性依赖性效果

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Previous studies demonstrate profound sex-specific patterns of white matter microstructural neurodevelopment (i.e. fractional anisotropy; FA, and mean diffusivity; MD) during adolescence. While alcohol use has been associated with alterations in FA and MD, no studies have addressed the potential for sex-specific, alcohol-dose dependent effects, during development. This prospective longitudinal study (2-4 visits, 310 total scans) used voxel-wise multilevel modeling, in 132 (68 female) adolescents (ages 12-21), to assess the sex-specific effects of lifetime alcohol use on FA and MD, during development. Follow-up analyses tested the role of sex hormones, testosterone and estradiol, in explaining the effects of alcohol use on FA and MD. In the splenium of the corpus callosum and posterior thalamic radiation, male adolescents demonstrated lower FA and greater MD as a function of more lifetime alcohol use, while female adolescents demonstrated the opposite. Further, significant associations between sex hormones and FA/MD partially explained the effect of alcohol use on FA and MD in male adolescents. These results provide evidence for sex-specific and dose-related effects of alcohol use on white matter microstructure, which are partially explained by sex hormones, and highlight the importance of studying sex and hormones when investigating the effects of alcohol use on the adolescent brain.
机译：之前的研究表明，青春期白质微结构神经发育（即分数各向异性；FA和平均扩散率；MD）具有深刻的性别特异性模式。虽然饮酒与FA和MD的改变有关，但没有研究表明在发育过程中存在性别特异性、酒精剂量依赖性影响的可能性。这项前瞻性纵向研究（2-4次随访，310次总扫描）在132名（68名女性）青少年（12-21岁）中采用体素水平的多水平建模，以评估在发育过程中终生饮酒对FA和MD的性别特异性影响。后续分析测试了性激素、睾酮和雌二醇在解释饮酒对FA和MD的影响方面的作用。在胼胝体的脾和丘脑后辐射中，男性青少年表现出较低的FA和较高的MD，这是长期饮酒的结果，而女性青少年则表现出相反的结果。此外，性激素与FA/MD之间的显著相关性部分解释了酒精使用对男性青少年FA和MD的影响。这些结果为酒精使用对大脑白质微观结构的性别特异性和剂量相关影响提供了证据，这在一定程度上是由性激素解释的，并强调了在调查酒精使用对青少年大脑的影响时研究性和激素的重要性。

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