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First episode psychosis moderates the effect of gray matter volume on cognition

机译：第一集精神病调节灰质体积对认知的影响

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Abstract Patients with first episode psychosis (FEP) present with cognitive deficits and volume differences in certain brain areas. Brain volumetric information further correlates with cognitive testing, and multiple brain areas shows different strengths of correlation with the cognitive functions being tested. Traditionally, these cognitive functions are independently related to volumetric differences, but these functions share variance. Failing to account for this aspect of cognition hinders the proper representation of cognition in neuroimaging studies. We used modeling methods which account for this shared variance to investigate the differences of correlations between cognitive abilities and brain areas. A multiple-groups structured equation model (SEM) approach was used to design and test a model representing the relation between gray matter volumetric data and neuropsychological test scores in a sample of 100 Brazilian FEP patients and 94 controls. Models with a latent variable formed by neurological measures and reflecting cognitive measures performed better on fit tests. FEP moderated the relation between gray matter volumes and cognition by altering the profile of correlations between groups. This moderation had a large effect size. SEM provides a fine grained picture of the interdependence of structural brain changes and cognition. Highlights ? Psychosis is a dimensional construct and is analysed with appropriate methods. ? Analysis of psychosis using structural equation modeling. ? Psychosis moderated the relation between brain structural changes and cognition. ? SEM provides a finer grained picture of the brain structure-cognition correlations.
机译：摘要首发精神病（FEP）患者在某些脑区存在认知缺陷和体积差异。大脑体积信息进一步与认知测试相关，多个大脑区域与被测试的认知功能表现出不同的相关性强度。传统上，这些认知功能与体积差异独立相关，但这些功能共享方差。未能解释认知的这一方面妨碍了神经影像学研究中认知的正确表征。我们使用解释这种共同方差的建模方法来研究认知能力和大脑区域之间的相关性差异。在100名巴西FEP患者和94名对照者的样本中，采用多组结构方程模型（SEM）方法设计并测试了一个模型，该模型代表了灰质体积数据与神经心理学测试分数之间的关系。由神经测量和反映认知测量组成的潜在变量模型在拟合测试中表现更好。FEP通过改变各组之间的相关性来调节灰质体积和认知之间的关系。这种节制对大小有很大的影响。扫描电镜（SEM）提供了大脑结构变化和认知相互依赖的精细图像。亮点？精神病是一种维度结构，并用适当的方法进行分析？使用结构方程模型分析精神病？精神病缓和了大脑结构变化与认知之间的关系？扫描电镜（SEM）提供了大脑结构与认知相关性的更精细的图像。

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