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首页> 外文期刊>Psychiatry Research. Neuroimaging >Regional decrease in gray matter volume is related to body dissatisfaction in anorexia nervosa
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Regional decrease in gray matter volume is related to body dissatisfaction in anorexia nervosa

机译：灰质体积的区域降低与厌食症神经系统的身体不满相关

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摘要

Anorexia nervosa (AN) is a psychiatric disorder, in which the prognosis for some patients is poor. The etiology and effective treatments for AN have not been established. We examined morphometric changes in the brain of AN and clarified how the changes were associated with symptoms and pathophysiology. We enrolled 52 participants: 7 with the restrictive type of AN, 13 with the binge-eating/purging type, 3 with eating disorder not otherwise specified, and 29 healthy controls. Participants underwent T1-weighted MRI. Group differences between patients and controls in gray matter volume (GMV) were analyzed using voxel-based morphometry. Age and body mass index (BMI) were considered covariates. Correlations between regional GMVs and drive for thinness and body dissatisfaction were examined. Patients had decreased GMV in the superior/middle temporal gyrus (STG/MTG), pulvinar, and superior frontal gyrus after correction for age and BMI, and in the STG/MTG, middle frontal gyrus, and cingulate after correction for age. A correlational group difference was detected for body dissatisfaction and GMV in the STG. Our findings suggest that decreased GMV in the STG is related to body dissatisfaction that could come from impaired visuospatial perception, together with GMV decreases in several regions, which may be involved in development of AN.
机译：神经性厌食症（AN）是一种精神疾病，部分患者预后不佳。AN的病因和有效治疗尚未确定。我们检查了AN患者大脑的形态计量学变化，并阐明了这些变化与症状和病理生理学的关系。我们招募了52名参与者：7名为限制型AN，13名为暴饮暴食/净化型，3名为未另行说明的饮食障碍，以及29名健康对照。参与者接受了T1加权MRI检查。使用基于体素的形态计量学分析患者和对照组在灰质体积（GMV）方面的组间差异。年龄和体重指数（BMI）被认为是协变量。研究了区域性GMV与瘦和身体不满意的驱动力之间的相关性。校正年龄和BMI后，患者的上/中颞回（STG/MTG）、枕叶回和上额叶回的GMV降低，校正年龄后，STG/MTG、中额叶回和扣带回的GMV降低。在STG中检测到身体不满意和GMV的相关组差异。我们的研究结果表明，STG中GMV的降低与身体不满意有关，而身体不满意可能是由于视觉空间知觉受损，以及几个区域GMV的降低，这可能与视觉障碍的发展有关。

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  • 来源
    《Psychiatry Research. Neuroimaging》 |2017年第2017期|共8页
  • 作者

    Kohmura Kunihiro; Adachi Yasunori; Tanaka Satoshi; Katayama Hiroto; Imaeda Miho; Kawano Naoko; Nishioka Kazuo; Ando Masahiko; Iidaka Tetsuya; Ozaki Norio;

  • 作者单位

    Nagoya Univ Dept Psychiat Grad Sch Med 65 Tsurumai Nagoya Aichi 4668550 Japan;

    Nagoya Univ Dept Psychiat Grad Sch Med 65 Tsurumai Nagoya Aichi 4668550 Japan;

    Nagoya Univ Hosp Dept Psychiat Nagoya Aichi Japan;

    Nagoya Univ Dept Psychiat Grad Sch Med 65 Tsurumai Nagoya Aichi 4668550 Japan;

    Nagoya Univ Dept Psychiat Grad Sch Med 65 Tsurumai Nagoya Aichi 4668550 Japan;

    Nagoya Univ Inst Innovat Future Soc Nagoya Aichi Japan;

    Nagoya Univ Dept Psychiat Grad Sch Med 65 Tsurumai Nagoya Aichi 4668550 Japan;

    Nagoya Univ Hosp Ctr Adv Med &

    Clin Res Nagoya Aichi Japan;

    Nagoya Univ Grad Sch Med Dept Phys &

    Occupat Therapy Nagoya Aichi Japan;

    Nagoya Univ Dept Psychiat Grad Sch Med 65 Tsurumai Nagoya Aichi 4668550 Japan;

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  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
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