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首页> 外文期刊>Psychiatry Research. Neuroimaging >Striatal changes in Parkinson disease: An investigation of morphology, functional connectivity and their relationship to clinical symptoms
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Striatal changes in Parkinson disease: An investigation of morphology, functional connectivity and their relationship to clinical symptoms

机译：帕金森病的纹状体变化：对形态，功能性连通性及其与临床症状的关系的调查

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We sought to investigate morphological and resting state functional connectivity changes to the striatal nuclei in Parkinson disease (PD) and examine whether changes were associated with measures of clinical function. Striatal nuclei were manually segmented on 3T-T1 weighted MRI scans of 74 PD participants and 27 control subjects, quantitatively analysed for volume, shape and also functional connectivity using functional MRI data. Bilateral caudate nuclei and putamen volumes were significantly reduced in the PD cohort compared to controls. When looking at left and right hemispheres, the PD cohort had significantly smaller left caudate nucleus and right putamen volumes compared to controls. A significant correlation was found between greater atrophy of the caudate nucleus and poorer cognitive function, and between greater atrophy of the putamen and more severe motor symptoms. Resting-state functional MRI analysis revealed altered functional connectivity of the striatal structures in the PD group. This research demonstrates that PD involves atrophic changes to the caudate nucleus and putamen that are linked to clinical dysfunction. Our work reveals important information about a key structure-function relationship in the brain and provides support for caudate nucleus and putamen atrophy as neuroimaging biomeasures in PD.
机译：我们试图研究帕金森病（PD）纹状体细胞核的形态学和静息状态功能连接变化，并检查这些变化是否与临床功能指标相关。在74名PD受试者和27名对照受试者的3T-T1加权MRI扫描上手动分割纹状体核，并使用功能性MRI数据对其体积、形状和功能连接进行定量分析。与对照组相比，PD组的双侧尾状核和壳核体积显著减少。当观察左右半球时，PD组的左尾状核和右壳核体积明显小于对照组。尾状核萎缩程度越大，认知功能越差，壳核萎缩程度越大，运动症状越严重，两者之间存在显著相关性。静息状态功能MRI分析显示PD组纹状体结构的功能连接改变。这项研究表明，PD涉及尾状核和壳核的萎缩性变化，这与临床功能障碍有关。我们的工作揭示了大脑中关键结构-功能关系的重要信息，并为尾核和壳核萎缩作为PD的神经影像生物测量提供了支持。

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