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首页> 外文期刊>Psychiatry Research. Neuroimaging >Lost emotion: Disrupted brain-based tracking of dynamic affective episodes in anxiety and depression
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Lost emotion: Disrupted brain-based tracking of dynamic affective episodes in anxiety and depression

机译：失去了情感：扰乱了脑追踪焦虑和抑郁动态情感发作的跟踪

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摘要

In our day-to-day lives we are confronted with dynamic sensory inputs that elicit a continuously evolving emotional response. Insight into the brain basis of the dynamic nature of emotional reactivity may be critical for understanding chronic symptoms of anxiety and depression. Here, individuals with generalized anxiety disorder, major depressive disorder, and healthy controls watched a video with dynamic affective content while fMRI activity was recorded. Across all participants there was a large-scale tracking of affective content in emotion processing regions and the default mode network. Anxious and depressed individuals displayed less brain-based coupling within these regions and the extent of this uncoupling correlated with variability in emotional numbing. Thus, abnormal neural tracking of affective information during dynamic emotional episodes appears to represent a disconnection between affective cues in the environment and an individual's response to these cues providing a putative neural basis for context insensitive affective reactivity and emotional numbing.
机译：在我们的日常生活中，我们面临着动态的感官输入，这些输入会引发不断演变的情绪反应。深入了解情绪反应的动态性质的大脑基础，对于理解焦虑和抑郁的慢性症状可能至关重要。在这里，患有广泛性焦虑症、重度抑郁症和健康对照者在记录功能磁共振成像活动的同时，观看了一段包含动态情感内容的视频。在所有参与者中，对情绪处理区域和默认模式网络中的情感内容进行了大规模跟踪。焦虑和抑郁的个体在这些区域内表现出较少的基于大脑的耦合，这种耦合的程度与情绪麻木的变异性相关。因此，在动态情绪发作期间，对情感信息的异常神经跟踪似乎代表了环境中的情感线索与个体对这些线索的反应之间的脱节，为上下文不敏感的情感反应和情感麻木提供了假定的神经基础。

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