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首页> 外文期刊>Psychiatry Research. Neuroimaging >Altered functional connectivity in brain networks underlying self-referential processing in delusions of reference in schizophrenia
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Altered functional connectivity in brain networks underlying self-referential processing in delusions of reference in schizophrenia

机译：精神分裂症妄想中的脑网络中脑网络中的功能连通性改变

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Delusions of reference in schizophrenia are thought to result from misattributions of self-relevance to neutral events. Activation of regions within the cortical midline structures (CMS; e.g., medial prefrontal cortex, cingulate cortex, and precuneus) have been previously associated with self-referential processing in schizophrenia patients; however, the specificity of this pattern to individuals with current delusions of reference has yet to be determined. In the present study, we identified functional brain networks that underlie self-referential processing using task-based multivariate functional connectivity. Healthy control subjects (n=15) and schizophrenia patients with (n=14) and without (n=13) current delusions of reference were shown ambiguous statements while undergoing functional magnetic resonance imaging, and evaluated whether these statements were thought to be specifically about them. Our results revealed two functionally distinct CMS networks that differed between patients and controls during self-referential processing: a posterior CMS network, which showed muted deactivity in non-delusional patients; and an anterior CMS network, in which delusional patients demonstrated hyperactivity. Furthermore, activity within the anterior CMS network across the three groups showed a linear pattern of increasing activity associated with greater intensity of delusions of reference, suggesting that hyperactivity in this network may underlie delusions of reference.
机译：精神分裂症患者的参照错觉被认为是由于错误地将自我关联归因于中性事件所致。皮质中线结构（CMS；例如内侧前额叶皮质、扣带回皮质和楔前叶）内区域的激活以前与精神分裂症患者的自我参照加工有关；然而，这种模式对目前存在参照错觉的个体的特异性尚未确定。在本研究中，我们利用基于任务的多元功能连通性确定了作为自我参照加工基础的功能性大脑网络。健康对照组受试者（n=15）和精神分裂症患者（n=14）在接受功能性磁共振成像时，出现（n=13）参考妄想，并评估这些妄想是否与他们有关。我们的研究结果揭示了两个功能不同的CMS网络，在自我参照过程中，患者和对照组之间存在差异：后CMS网络，在非妄想患者中表现出沉默的失活；以及一个前部CMS网络，其中妄想患者表现出多动症。此外，三组患者的前CMS网络内的活动表现出与更大程度的参考妄想相关的活动增加的线性模式，这表明该网络中的过度活动可能是参考妄想的基础。

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