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首页> 外文期刊>Psychiatry Research. Neuroimaging >Mismatch negativity-indexed auditory change detection of speech sounds in early and chronic schizophrenia
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Mismatch negativity-indexed auditory change detection of speech sounds in early and chronic schizophrenia

机译：不匹配的消极性索引检测早期和慢性精神分裂症的语音声音

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Auditory change detection, as indexed by the EEG-derived mismatch negativity, has been demonstrated to be dysfunctional in chronic schizophrenia using both pure-tone and speech (phoneme) sounds. It is unclear, however, whether reduced MMN amplitudes to speech sound deviants are observed within the first 5 years of the illness. The present study investigated MMNs elicited by across-vowel (phoneme) change in early schizophrenia (ESZ; Experiment 1) as well as chronic schizophrenia (CSZ; Experiment 2). In both experiments, clinical and control participants were presented the Finnish phoneme /e/ (standard; P = .90) and the Finnish phoneme /o/ (deviant; P = .10) within an oddball paradigm. In experiment 2 we report significantly reduced MMN amplitudes in CSZ relative to HCs, but no differences were found when comparing ESZ and HC in experiment 1. Additionally, in our clinical samples, MMN amplitudes were correlated with symptom scores. These findings suggest that early detection of phonetic change may be impaired in chronic schizophrenia, but not early in the progression of the illness. As MMN reductions only emerged in patients with a longer course of illness, and appeared to change with symptom severity, this suggests a dynamic change in the early auditory processing of language over time in schizophrenia.
机译：听觉变化检测，如EEG衍生的失配负性指数所示，已被证明在慢性精神分裂症患者中，使用纯音和语音（音素）声音是功能失调的。然而，目前尚不清楚在发病的前5年内，是否观察到语音异常患者的MMN振幅降低。本研究调查了早期精神分裂症（ESZ；实验1）和慢性精神分裂症（CSZ；实验2）中跨元音（音位）变化引起的MMN。在这两个实验中，临床和对照参与者在一个奇怪的范式中被呈现芬兰音素/e/（标准；P=0.90）和芬兰音素/o/（偏差；P=0.10）。在实验2中，我们报告CSZ相对于HCs的MMN振幅显著降低，但在实验1中比较ESZ和HC时未发现差异。此外，在我们的临床样本中，MMN振幅与症状评分相关。这些发现表明，在慢性精神分裂症患者中，语音变化的早期检测可能会受损，但在疾病进展的早期则不会。由于MMN的减少只出现在病程较长的患者中，并且似乎随着症状的严重程度而改变，这表明精神分裂症患者的早期听觉语言处理随着时间的推移发生了动态变化。

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