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首页> 外文期刊>Psychiatry Research. Neuroimaging >Cortical thinning in preschoolers with maladaptive guilt
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Cortical thinning in preschoolers with maladaptive guilt

机译：患有适用于适用的内疚者的皮质稀疏

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Maladaptive guilt is a central symptom of preschool-onset depression associated with severe psychopathology in adolescence and adulthood. Although studies have found that maladaptive guilt is associated with structural alterations in the anterior insula (AI) and dorsomedial prefrontal cortex (dmPFC) in middle childhood and adolescence, no study has examined structural neural correlates of maladaptive guilt in preschool, when this symptom first emerges. This study examined a pooled sample of 3-to 6-year-old children (N = 76; 40.8% female) from two studies, both which used the same type of magnetic resonance imaging scanner and conducted diagnostic interviews for depression that included clinician ratings of whether children met criteria for maladaptive guilt. Preschoolers with maladaptive guilt displayed significantly thinner dmPFC than children without this symptom. Neither children's depressive severity nor their vegetative or other emotional symptoms of depression were associated with dmPFC thickness, suggesting that dmPFC thinning is specific to maladaptive guilt. Neither AI gray matter volume or thickness nor dmPFC gray matter volume differed between children with and without maladaptive guilt. This study is the first to identify a structural biomarker for a specific depressive symptom in preschool. Findings may inform neurobiological models of the development of depression and aid in detection of this symptom.
机译：适应不良负罪感是学龄前抑郁症的中心症状，与青春期和成年期的严重精神病理学有关。尽管研究发现，儿童中期和青少年时期，适应不良内疚感与前岛叶（AI）和背内侧前额叶皮质（dmPFC）的结构改变有关，但还没有研究检测学龄前儿童首次出现这种症状时，与适应不良内疚感相关的结构神经因素。本研究对两项研究中的3至6岁儿童（N=76；40.8%为女性）进行了汇总样本研究，这两项研究都使用了相同类型的磁共振成像扫描仪，并对抑郁症进行了诊断性访谈，其中包括临床医生对儿童是否符合适应不良内疚标准的评分。有适应不良内疚感的学龄前儿童的dmPFC显著低于没有这种症状的儿童。儿童的抑郁严重程度、植物人或其他抑郁情绪症状均与dmPFC厚度无关，这表明dmPFC变薄与不适应内疚有关。无论是AI灰质体积或厚度，还是dmPFC灰质体积，在有和没有适应不良内疚的儿童之间都没有差异。这项研究首次确定了学龄前儿童特定抑郁症状的结构生物标志物。这些发现可能会为抑郁症发展的神经生物学模型提供信息，并有助于检测这种症状。

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