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首页> 外文期刊>Psychiatry Research. Neuroimaging >Altered olfactory processing and increased insula activity in patients with obsessive-compulsive disorder: An fMRI study
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Altered olfactory processing and increased insula activity in patients with obsessive-compulsive disorder: An fMRI study

机译：强迫症患者的嗅觉加工和肠内活性增加：FMRI研究

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摘要

Obsessive-compulsive disorder (OCD) patients show increased insula activation to disgust-inducing images compared to healthy controls (HC). We explored whether this disgust reactivity was also present in the olfactory domain by conducting the first fMRI study of olfaction in OCD. Neural activation in response to pleasant and unpleasant odors (vs. unscented air) was investigated in 15 OCD and 15 HC participants using fMRI. OCD participants (vs. HC) had increased left anterior insula activation to unpleasant odors (vs. unscented air), which positively correlated with their disgust sensitivity and ratings of the unpleasantness and intensity of those odors. OCD participants (vs. HC) showed increased activation of caudate nucleus and left anterior and posterior insula to pleasant odors (vs. unscented air), which positively correlated with their OCD symptom severity, trait anxiety, frequency of feeling disgust, and odor intensity ratings. OCD participants had increased anterior insula activation to both pleasant and unpleasant odors, which correlated with their OCD symptoms, anxiety, disgust sensitivity, and frequency of feeling disgust. OCD patients might have a negative cognitive bias and experience all stimuli, regardless of valence, as being more unpleasant than healthy people. These findings further elucidate the neural underpinnings of OCD and may contribute to more effective treatments.
机译：与健康对照组（HC）相比，强迫症（OCD）患者对恶心诱导图像的脑岛激活增加。我们通过首次对强迫症患者的嗅觉进行功能磁共振成像研究，探讨了这种厌恶反应是否也存在于嗅觉领域。使用功能磁共振成像对15名强迫症和15名HC受试者对愉快和不愉快气味（与无味空气）的神经激活进行了研究。强迫症参与者（与HC相比）对不愉快气味（与无味空气相比）的左前岛叶激活增加，这与他们的厌恶敏感性以及对这些气味的不愉快程度和强度的评分呈正相关。强迫症参与者（与HC相比）表现出尾状核和左前岛叶和后岛叶对愉快气味的激活增加（与无味空气相比），这与他们的强迫症症状严重程度、特质焦虑、恶心频率和气味强度评分呈正相关。强迫症参与者对愉快和不愉快气味的前岛叶激活增加，这与他们的强迫症症状、焦虑、厌恶敏感度和感到厌恶的频率相关。强迫症患者可能有消极的认知偏见，并且经历的所有刺激，无论其价态如何，都比健康人更不愉快。这些发现进一步阐明了强迫症的神经基础，可能有助于更有效的治疗。

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