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首页> 外文期刊>Psychiatry Research. Neuroimaging >A study of tryptophan, kynurenine and serotonin transporter in first-episode drug-naive major depressive disorder
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A study of tryptophan, kynurenine and serotonin transporter in first-episode drug-naive major depressive disorder

机译：第一集药物 - 幼稚主要抑郁症中色氨酸，犬育素和血清素转运蛋白的研究

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摘要

Major depressive disorder (MDD) is associated with the disharmonic functioning of the serotonin system. The serotonin system is mainly modulated by the serotonin transporter (SERT) which regulates serotonin uptake and the metabolism of its precursor, tryptophan and following kynurenine pathway. Currently, there is a lack of research examining both markers concurrently in MDD. This study evaluated the alterations and interrelationships of both markers in first-episode drug-naive MDD patients. Thirty-three MDD patients and 33 age- and sex-matched healthy controls (HC) were recruited. The SERT availability were comparable between two groups in the midbrain, thalamus, caudate, and putamen. The kynurenine/tryptophan ratio which indicates tryptophan metabolism was lower in MDD than HC with no group difference in the tryptophan or kynurenine concentration. A negative correlation between the midbrain SERT availability and kynurenine concentration in HC was found. For the subgroup of HC with high kynurenine/tryptophan ratio, the SERT availability was positively associated with the kynurenine/tryptophan ratio and negatively correlated with tryptophan or kynurenine concentration. This study demonstrated the altered tryptophan metabolism and the relationship between tryptophan metabolism and the SERT availability in first-episode drug-naive MDD patients, which gave a new insight towards the future investigation of the pathophysiology of MDD.
机译：重度抑郁症（MDD）与5-羟色胺系统的不和谐功能有关。5-羟色胺系统主要由5-羟色胺转运体（SERT）调节，SERT调节5-羟色胺的摄取及其前体色氨酸的代谢，并遵循犬尿氨酸途径。目前，缺乏同时检测MDD中两种标记物的研究。本研究评估了首次服用药物的MDD患者两种标志物的变化及其相互关系。招募了33名MDD患者和33名年龄和性别匹配的健康对照（HC）。两组在中脑、丘脑、尾状核和壳核的SERT可用性相当。犬尿氨酸/色氨酸比值表明，MDD患者的色氨酸代谢低于HC患者，且色氨酸或犬尿氨酸浓度无组间差异。发现HC中脑SERT可用性与犬尿氨酸浓度呈负相关。对于高犬尿氨酸/色氨酸比值的HC亚组，SERT有效性与犬尿氨酸/色氨酸比值呈正相关，与色氨酸或犬尿氨酸浓度呈负相关。本研究证实了首次服用药物的MDD患者色氨酸代谢的改变，以及色氨酸代谢与SERT可用性之间的关系，为MDD病理生理学的未来研究提供了新的视角。

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