Examination of preliminary behavioral and effective connectivity findings from treatment response to citalopram in cocaine use disorder: A dynamic causal modeling study

Snyder A. D.; Zuniga E.; Ma L.; Steinberg J. L.; Woisard K.; Narayana P. A.; Lane S.; Schmitz J.; Moeller F. G.

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Examination of preliminary behavioral and effective connectivity findings from treatment response to citalopram in cocaine use disorder: A dynamic causal modeling study

机译：从Cocaine使用障碍中对西酞普兰治疗反应的初步行为和有效连通性调查结果：动态因果造型研究

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We sought effective (directional) connectivity parameters associated with response to citalopram in cocaine use disorder (CUD) by conducting a functional magnetic resonance imaging (fMRI) experiment with participants diagnosed with CUD (n = 13) and matched healthy controls (HC; n = 17). CUD participants showed a positive correlation between bilateral DLPFC-to-putamen effective connectivity and treatment effectiveness score. These preliminary results support further investigation of prefrontal-striatal interactions in response to treatment in CUD.

机译：我们通过对确诊为可卡因使用障碍（CUD）的参与者（n=13）和匹配的健康对照者（HC；n=17）进行功能磁共振成像（fMRI）实验，寻找与可卡因使用障碍（CUD）中西酞普兰反应相关的有效（定向）连接性参数。CUD参与者在双侧DLPFC与壳核有效连通性和治疗效果评分之间显示出正相关。这些初步结果支持对CUD治疗后前额叶-纹状体相互作用的进一步研究。

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来源
《Psychiatry Research. Neuroimaging》 |2020年第1期|共3页
作者
Snyder A. D.; Zuniga E.; Ma L.; Steinberg J. L.; Woisard K.; Narayana P. A.; Lane S.; Schmitz J.; Moeller F. G.;
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作者单位

Virginia Commonwealth Univ Inst Drug &

Alcohol Studies Richmond VA USA;

Virginia Commonwealth Univ Inst Drug &

Alcohol Studies Richmond VA USA;

Virginia Commonwealth Univ Inst Drug &

Alcohol Studies Richmond VA USA;

Virginia Commonwealth Univ Inst Drug &

Alcohol Studies Richmond VA USA;

Virginia Commonwealth Univ Inst Drug &

Alcohol Studies Richmond VA USA;

Univ Texas Hlth Sci Ctr Houston Dept Diagnost &

Intervent Imaging Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston Grad Sch Biomed Sci Program Neurosci Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston Faillace Dept Psychiat &

Behav Sci Houston TX 77030 USA;

Virginia Commonwealth Univ Inst Drug &

Alcohol Studies Richmond VA USA;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Cocaine use disorder; Impulsivity; Selective serotonin reuptake inhibitor; Ssri; Effective connectivity; Citalopram;

机译：可卡因使用障碍;冲动;选择性血清素再摄取抑制剂;SSRI;有效的连通性;西酞普兰;

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机译：药物添加治疗手册。手册4.可卡因成瘾药物咨询：协同可卡因治疗研究模型

Examination of preliminary behavioral and effective connectivity findings from treatment response to citalopram in cocaine use disorder: A dynamic causal modeling study

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