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首页> 外文期刊>Psychiatry Research. Neuroimaging >Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis
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Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis

机译：枕骨γ-氨基丁酸和谷氨酸 - 谷氨酰胺改变主要抑郁症：MRS研究和荟萃分析

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摘要

The neurotransmitters GABA and glutamate have been suggested to play a role in Major Depressive Disorder (MDD) through an imbalance between cortical inhibition and excitation. This effect has been highlighted in higher brain areas, such as the prefrontal cortex, but has also been posited in basic sensory cortices. Based on this, magnetic resonance spectroscopy (MRS) was used to investigate potential changes to GABA+ and glutamate+glutamine (Glx) concentrations within the occipital cortex in MDD patients (n = 25) and healthy controls (n = 25). No difference in occipital GABA+ or Glx concentrations, nor in the GABA+/Glx ratio, was found between groups. An analysis of an extended MDD patient and unmatched control dataset (n = 90) found no correlation between metabolite concentrations and depressive symptoms. These results were integrated with prior studies through metabolite-specific meta-analyses, revealing no difference in occipital GABA and Glx concentrations between patients and controls. An effect of publication year on GABA group differences was found, suggesting that previously reported results may have been artifacts of measurement accuracy. Taken together, our results suggest that, contrary to some prior reports, MRS measurements of occipital GABA and Glx do not differ between MDD patients and controls.
机译：神经递质GABA和谷氨酸被认为通过皮层抑制和兴奋之间的不平衡在重度抑郁症（MDD）中发挥作用。这种效应在高级大脑区域，如前额叶皮质，得到了强调，但在基本感觉皮质也得到了证实。基于此，利用磁共振波谱（MRS）研究MDD患者（n=25）和健康对照组（n=25）枕叶皮质内GABA+和谷氨酸+谷氨酰胺（Glx）浓度的潜在变化。两组之间的枕叶GABA+或Glx浓度以及GABA+/Glx比值均无差异。一项对扩展的MDD患者和不匹配的对照数据集（n=90）的分析发现，代谢物浓度与抑郁症状之间没有相关性。这些结果通过代谢物特异性荟萃分析与之前的研究相结合，显示患者和对照组之间枕叶GABA和Glx浓度没有差异。发现发表年份对GABA组差异的影响，表明之前报告的结果可能是测量准确性的伪影。综上所述，我们的结果表明，与之前的一些报道相反，MDD患者和对照组的枕叶GABA和Glx的MRS测量没有差异。

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