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首页> 外文期刊>Psychiatry Research. Neuroimaging >Neural correlates of script-driven imagery in adolescents with interpersonal traumatic experiences: A pilot study
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Neural correlates of script-driven imagery in adolescents with interpersonal traumatic experiences: A pilot study

机译：人际创牙体验中的青少年脚本驱动图像的神经相关性：试验研究

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摘要

In adults, trauma imagery has proven to be a useful tool to assess the neural mechanisms of psychological trauma processing. In adolescents, heterogeneous results could be found for other tasks, however, a trauma imagery paradigm has not been evaluated. For this purpose, we investigated a trauma imagery paradigm with control scripts to assess neural correlates of traumatic experiences in youth. 15 adolescents, who had experienced a traumatic interpersonal event in the past and have developed clinically relevant symptoms, underwent an fMRI scan while listening to their individual trauma-versus two control scripts (positive/negative). We analysed a parametric contrast of the imagery phases (trauma negative > positive) which revealed activity in the thalamus, dorsal anterior cingulate cortex, cuneus, dorsomedial prefrontal cortex and amygdala. Additionally, amygdala-activity correlated positively with depression-symptom-severity. Our data provide evidence for the feasibility of fMRI during a trauma imagery task in adolescents to investigate networks previously related to hyperarousal in adults with PTSD. Further, we demonstrate the specificity of the activated networks for trauma imagery as compared to imagery of other emotional situations. The task might be particularly useful to evaluate neural correlates of treatment in adolescents when hyperarousal is a target symptom.
机译：在成年人中，创伤图像已被证明是评估心理创伤处理的神经机制的有用工具。在青少年中，其他任务的结果可能存在异质性，然而，尚未评估创伤想象范式。为此，我们研究了一种创伤想象范式，并用控制脚本来评估青少年创伤经历的神经相关性。15名青少年在过去曾经历过创伤性人际事件，并出现了临床相关症状，他们在听各自的创伤和两个对照脚本（阳性/阴性）时进行了功能磁共振扫描。我们分析了图像期（创伤阴性>阳性）的参数对比，显示丘脑、背前扣带回皮质、楔部、背内侧前额叶皮质和杏仁核的活动。此外，杏仁核活动与抑郁症状的严重程度呈正相关。我们的数据为功能磁共振成像在青少年创伤成像任务中的可行性提供了证据，以调查先前与创伤后应激障碍成年患者过度觉醒相关的网络。此外，我们还证明了创伤意象激活网络与其他情绪情境意象相比的特殊性。当过度觉醒是一种目标症状时，这项任务对于评估青少年治疗的神经相关性可能特别有用。

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