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首页> 外文期刊>Psychiatry Research. Neuroimaging >Structural and functional neuroimaging changes associated with cognitive impairment and dementia in Parkinson's disease
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Structural and functional neuroimaging changes associated with cognitive impairment and dementia in Parkinson's disease

机译：与认知障碍和婴儿疾病疾病相关的结构和功能性神经影像变化

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This study seeks a better understanding of possible pathophysiological mechanisms associated with cognitive impairment and dementia in Parkinson's disease using structural and functional MRI. We investigated restingstate functional connectivity of important subdivisions of the caudate nucleus, putamen and thalamus, and also how the morphology of these structures are impacted in the disorder. We found cognitively unimpaired Parkinson's disease subjects (n = 33), compared to controls (n = 26), display increased functional connectivity of the dorsal caudate, anterior putamen and mediodorsal thalamic subdivisions with areas across the frontal lobe, as well as reduced functional connectivity of the dorsal caudate with posterior cortical and cerebellar regions. Compared to cognitively unimpaired subjects, those with mild cognitive impairment (n = 22) demonstrated reduced functional connectivity of the mediodorsal thalamus with the paracingulate cortex, while also demonstrating increased functional connectivity of the mediodorsal thalamus with the posterior cingulate cortex, compared to subjects with dementia (n = 17). Extensive volumetric and surface-based deflation was found in subjects with dementia compared to cognitively unimpaired Parkinson's disease participants and controls. Our research suggests that structures within basal ganglia-thalamocortical circuits are implicated in cognitive impairment and dementia in Parkinson's disease, with cognitive impairment and dementia associated with a breakdown in functional connectivity of the mediodorsal thalamus with para- and posterior cingulate regions of the brain respectively.
机译：本研究旨在通过结构和功能磁共振成像，更好地了解帕金森病认知障碍和痴呆的可能病理生理机制。我们研究了尾状核、壳核和丘脑重要亚区的RESTTINGSTATE功能连通性，以及这些结构的形态如何在该疾病中受到影响。我们发现，与对照组（n=26）相比，认知功能未受损的帕金森病受试者（n=33）的背侧尾状核、前壳核和丘脑内侧亚区与额叶之间的功能连接增加，以及背侧尾状核与后皮质和小脑区域的功能连接减少。与认知功能正常的受试者相比，轻度认知障碍的受试者（n=22）表现出中嗅丘脑与扣带回旁皮质的功能连接减少，而与痴呆症受试者（n=17）相比，中嗅丘脑与扣带回后皮质的功能连接增加。与认知功能未受损的帕金森病参与者和对照组相比，痴呆患者中发现了广泛的体积性和表面性通货紧缩。我们的研究表明，基底节-丘脑-皮质回路内的结构与帕金森病的认知障碍和痴呆有关，认知障碍和痴呆分别与内侧丘脑与大脑扣带旁区和后部区域的功能连接中断有关。

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