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首页> 外文期刊>Psychiatry Research. Neuroimaging >Disrupted dynamic functional connectivity in right amygdalar subregions differentiates bipolar disorder from major depressive disorder
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Disrupted dynamic functional connectivity in right amygdalar subregions differentiates bipolar disorder from major depressive disorder

机译：右杏仁次区域中断的动态功能连通性与主要抑郁症的双相障碍不同

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Notwithstanding being the object of a growing field of clinical research, the investigation of the dynamic resting-state functional connectivity alterations in psychiatric illnesses is still in its early days. Current research on major depressive disorder (MDD) and bipolar disorder (BD) has evidenced abnormal resting-state functional connectivity (rsFC), especially in regions subserving emotional processing and regulation such as the amygdala. However, dynamic changes in functional connectivity within the amygdalar subregions in distinguishing BD and MDD has not yet been fully understood. In this paper, we aim at analyzing the patterns characterizing dynamic FC (dFC) in the right amygdala to investigate the differences between similarly depressed BD and MDD. A number of 40 BD patients, 61 MDD patients and 63 healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) at rest. Using the right-amygdala as seed region, we compared the dFC within three subdivisions, namely, laterobasal (LB), centromedial (CM) and superficial (SF) between all the groups. To do so, one-way ANOVA followed by post-hoc t-tests were employed. Compared to HCs, patients with BD had a decreased dFC between right LB and the left postcentral gyrus as well as an increased dFC between right CM and the right cerebellum.Compared to BD patients, patients with MDD showed a decreased dFC between right CM and the cerebellum and an increased dFC between right LB and the left postcentral gyrus. These findings present initial evidence that abnormal patterns of the right-amygdalar subregions shared by BD and MDD supports the differential pathophysiology of these disorders.
机译：尽管是一个不断增长的临床研究领域的研究对象，但对精神疾病中动态静息状态功能连接改变的研究仍处于早期阶段。目前对重度抑郁症（MDD）和双相情感障碍（BD）的研究表明，静息状态功能连通性（rsFC）异常，尤其是在杏仁核等情绪处理和调节区域。然而，在区分BD和MDD的过程中，杏仁核亚区内功能连接的动态变化尚未完全了解。在本文中，我们旨在分析右侧杏仁核中动态FC（dFC）的特征模式，以探讨类似抑郁的BD和MDD之间的差异。40名BD患者、61名MDD患者和63名健康对照者在休息时接受了功能性磁共振成像（fMRI）。以右侧杏仁核为种子区，我们比较了三个亚区的dFC，即侧基底区（LB）、中心内侧区（CM）和浅表区（SF）。为此，采用了单因素方差分析和事后t检验。与HCs相比，BD患者右侧LB和左侧中央后回之间的dFC降低，右侧CM和右侧小脑之间的dFC增加。与BD患者相比，MDD患者右侧CM和小脑之间的dFC降低，右侧LB和左侧中央后回之间的dFC增加。这些发现提供了初步证据，表明BD和MDD共有的右侧杏仁核亚区的异常模式支持了这些疾病的病理生理差异。

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