Altered phospholipid and high-energy phosphate metabolism in the basal ganglia and thalamus of severe obsessive compulsive patients with treatment resistance: A phosphorus 31 nuclear magnetic resonance spectroscopy study.

Hatchondo Laura; Vallee Alexandre; Vallee Rodolphe; Jaafari Nemat; Maillochaud Sylvie; Naudin Mathieu; Vallee Jean-Noel; Guillevin Remy; Guillevin Carole

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Altered phospholipid and high-energy phosphate metabolism in the basal ganglia and thalamus of severe obsessive compulsive patients with treatment resistance: A phosphorus 31 nuclear magnetic resonance spectroscopy study.

机译：基底神经节和丘疹的磷脂和高能磷酸盐代谢改变，治疗耐药性强迫患者：磷31核磁共振光谱研究。

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Introduction: Cerebral metabolism in obsessive-compulsive-disorder(OCD) has been the subject of numerous studies using proton magnetic resonance spectroscopy(MRS). Despite heterogeneous results, some studies have unraveled membrane turnover and energy metabolism abnormalities in different brain regions, suggesting that alterations in these processes may contribute to the pathophysiology. So far, no authors have explored phospholipids and high-energy phosphate metabolism using 31P-MRS, which allows in vivo quantification of phosphorus metabolites that are considered to be related to membrane turnover and energy metabolism.

机译：导言：强迫症（OCD）的脑代谢一直是质子磁共振波谱（MRS）研究的主题。尽管结果不一，但一些研究揭示了不同脑区的膜转换和能量代谢异常，表明这些过程的改变可能有助于病理生理学。到目前为止，还没有作者使用31P-MRS研究磷脂和高能磷酸盐代谢，31P-MRS允许在体内定量分析被认为与膜转换和能量代谢有关的磷代谢物。

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《Psychiatry Research. Neuroimaging》 |2021年第1期|共6页
作者
Hatchondo Laura; Vallee Alexandre; Vallee Rodolphe; Jaafari Nemat; Maillochaud Sylvie; Naudin Mathieu; Vallee Jean-Noel; Guillevin Remy; Guillevin Carole;
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作者单位

Poitiers Univ CNRS 7348 I3M Lab DACTIM MIS Team Lab Math Appl LMA Poitiers France;

Poitiers Univ CNRS 7348 I3M Lab DACTIM MIS Team Lab Math Appl LMA Poitiers France;

Poitiers Univ CNRS 7348 I3M Lab DACTIM MIS Team Lab Math Appl LMA Poitiers France;

Henri Laborit Hosp Clin Res Unit Psychiat Poitiers France;

Henri Laborit Hosp Clin Res Unit Psychiat Poitiers France;

Poitiers Univ CNRS 7348 I3M Lab DACTIM MIS Team Lab Math Appl LMA Poitiers France;

Picardie Jules Verne UPJV Univ Amiens Picardie Univ Hosp Amiens France;

Poitiers Univ CNRS 7348 I3M Lab DACTIM MIS Team Lab Math Appl LMA Poitiers France;

Poitiers Univ CNRS 7348 I3M Lab DACTIM MIS Team Lab Math Appl LMA Poitiers France;

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正文语种 eng
中图分类神经病学与精神病学;
关键词
Obsessive-compulsive disorders; Phosphorus magnetic resonance spectroscopy; Basal ganglia; Striatum; Thalamus;

机译：强迫症状;磷磁共振光谱;基础神经节;纹状体;丘脑;

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1. Analyzing Ph value, energy and phospholipid metabolism of various cerebral tumors and normal brain tissue with 31P magnetic resonance spectroscopy [J] . Wei Tan, Guangyao Wu, Junmo Sun 中国神经再生研究（英文版） . 2006,第003期
2. High-energy phosphate metabolism in the calf muscle during moderate isotonic exercise under different degrees of cuff compression: a phosphorus 31 magnetic resonance spectroscopy study. [J] . Greiner A, Esterhammer R, Pilav S, Journal of vascular surgery . 2005,第2期

机译：小腿肌肉在中等强度的运动过程中，不同程度的袖带受压时高能磷酸盐代谢：磷31磁共振波谱研究。
3. Altered phospholipid metabolism in schizophrenia: A phosphorus 31 nuclear magnetic resonance spectroscopy study [J] . Weber-FahrW., EnglischS., EsserA., Psychiatry Research. Neuroimaging . 2013,第3期

机译：精神分裂症中磷脂代谢的改变：磷31核磁共振波谱研究
4. 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients [J] . Paolo Fiorina, Roberto Bassi, Chiara Gremizzi, Acta Diabetologica . 2012,第1期

机译：31 磁共振波谱法（31 M-RS）检测了6个月缬沙坦治疗糖尿病和非糖尿病肾移植患者肾脏高能磷酸盐代谢的早期变化
5. Using Phosphorus-31 Nuclear Magnetic Resonance Spectroscopy to Characterize Organic Phosphorus in Environmental Samples [C] . Barbara J. Cade-Menun Organic Phosphorus Workshop . 2005

机译：使用磷核磁共振光谱在环境样品中表征有机磷
6. Mechanisms and pathways of inositol phosphate degradation: Evidence from phosphate oxygen stable isotope ratios and 31P nuclear magnetic resonance spectroscopy [D] . Wu, Jiangqi. 2014

机译：磷酸肌醇磷酸盐降解的机制和途径：来自磷酸盐稳定同位素比和31P核磁共振光谱的证据
7. Altered phosphorylation status phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. [O] . P. C. Dagnelie, J. D. Bell, S. C. Williams, 1993

机译：前列腺癌大鼠宿主肝脏中磷酸化状态磷脂代谢和糖异生的改变：一项31P磁共振波谱研究。
8. Evaluation of high-energy phosphate metabolism during cardioplegic arrest and reperfusion: a phosphorus-31 nuclear magnetic resonance study. [O] . A C Pernot, J S Ingwall, P Menasche, 1983

机译：心血停搏停滞和再灌注期间高能磷化代谢评价：磷-31核磁共振研究。
9. Investigation of the Potential of 31-Phosphorus Nuclear Magnetic Resonance Spectroscopy to Predict Radiation Sensitivity. [R] . Bowser, C. 1988

机译：31-磷核磁共振光谱预测辐射灵敏度的潜力研究。

Altered phospholipid and high-energy phosphate metabolism in the basal ganglia and thalamus of severe obsessive compulsive patients with treatment resistance: A phosphorus 31 nuclear magnetic resonance spectroscopy study.

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