Pharmacokinetics and pharmacodynamics of intravesical and intravenous TMX-101 and TMX-202 in a F344 rat model

Falke Johannes; Hulsbergen-van de Kaa Christina A.; Maj Roberto; Oosterwijk Egbert; Witjes Johannes Alfred

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Pharmacokinetics and pharmacodynamics of intravesical and intravenous TMX-101 and TMX-202 in a F344 rat model

机译：F344大鼠模型中膀胱内和静脉TMX-101和TMX-202的药代动力学和药效学

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Objectives: To evaluate and compare the pharmacokinetic and pharmacodynamic properties of 2 investigational Toll-like receptor 7 agonists, TMX-101, and TMX-202 after intravenous and intravesical administration in a rat model. TLR-7 agonists are successfully used as topical treatment for various (pre)malignant skin lesions and are now under investigation as intravesical therapy for non muscle-invasive bladder cancer.

机译：目的：在大鼠模型中，评估和比较静脉和膀胱内给药后两种Toll样受体7激动剂TMX-101和TMX-202的药代动力学和药效学特性。TLR-7激动剂已成功用于各种（前期）恶性皮肤病变的局部治疗，目前正在研究作为非肌肉浸润性膀胱癌的膀胱内治疗。

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来源
《Urologic oncology》 |2018年第5期|共7页
作者
Falke Johannes; Hulsbergen-van de Kaa Christina A.; Maj Roberto; Oosterwijk Egbert; Witjes Johannes Alfred;
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作者单位

Radboud Univ Nijmegen Med Ctr Dept Urol Nijmegen Netherlands;

Radboud Univ Nijmegen Med Ctr Dept Pathol Nijmegen Netherlands;

Telormedix SA Bioggio Switzerland;

Radboud Univ Nijmegen Med Ctr Dept Urol Nijmegen Netherlands;

Radboud Univ Nijmegen Med Ctr Dept Urol Nijmegen Netherlands;

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原文格式 PDF
正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
Immune modulator; Imiquimod; Non muscle-invasive bladder cancer; Pharmacodynamics; Pharmacokinetics; Toll-like receptor;

机译：免疫调节剂;Imiquimod;非肌肉侵袭性膀胱癌;药效学;药代动力学;令人伤害的受体;

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6. Pharmacokinetics and pharmacodynamics of intravesical and intravenous TMX-101 and TMX-202 in a F344 rat model [J] . Falke Johannes, Hulsbergen-van de Kaa Christina A., Maj Roberto, Urologic oncology . 2018,第5期

机译：F344大鼠模型中膀胱内和静脉TMX-101和TMX-202的药代动力学和药效学
7. A placebo-controlled efficacy study of the intravesical immunomodulators TMX-101 and TMX-202 in an orthotopic bladder cancer rat model [J] . Falke Johannes, Hulsbergen-van de Kaa Christina A., Maj Roberto, World journal of urology . 2018,第11期

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Pharmacokinetics and pharmacodynamics of intravesical and intravenous TMX-101 and TMX-202 in a F344 rat model

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