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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Antibody Profiles to P . falciparum Antigens Over Time Characterize Acute and Long-Term Malaria Exposure in an Area of Low and Unstable Transmission
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Antibody Profiles to P . falciparum Antigens Over Time Characterize Acute and Long-Term Malaria Exposure in an Area of Low and Unstable Transmission

机译：p的抗体谱。 恶性疟原虫抗原随时间表征急性和长期疟疾暴露在低和不稳定的传输区域中

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摘要

Prevalence and levels of antibodies to multiple Plasmodium falciparum antigens show promise as tools for estimating malaria exposure. In a highland area of Kenya with unstable transmission, we assessed the presence and levels of antibodies to 12 pre-erythrocytic and blood-stage P. falciparum antigens by multiplex cytometric bead assay or ELISA in 604 individuals in August 2007, with follow-up testing in this cohort in April 2008, April 2009, and May 2010. Four hundred individuals were tested at all four time points. During this period, the only substantial malaria incidence occurred from April to August 2009. Antibody prevalence in adults was high at all time points (> 70%) for apical membrane antigen 1, erythrocyte-binding antigen 175, erythrocyte-binding protein-2, glutamate rich protein (GLURP)-R2, merozoite surface protein (MSP) 1 (19), MSP-1 (42), and liver-stage antigen-1; moderate (30-70%) for GLURP-R0, MSP-3, and thrombospondin-related adhesive protein; and low (< 30%) for SE and circumsporozoite protein (CSP). Changes in community-wide malaria exposure were best reflected in decreasing antibody levels overtime for highly immunogenic antigens, and in antibody seroprevalence overtime for the less-immunogenic antigens. Over the 3 years, antibody levels to all antigens except CSP and schizont extract (SE) decreased in an age-dependent manner. Prevalence and levels of antibodies to all antigens except CSP and SE increased with age. Increases in antibody prevalence and levels to CSP and SE coincided with increases in community-wide malaria incidence. Antibody levels to multiple P. falciparum antigens decrease in the absence of consistent transmission. Multiplex assays that assess both the presence and level of antibodies to multiple pre-erythrocytic and blood-stage P. falciparum antigens may provide the most useful estimates of past and recent malaria transmission in areas of unstable transmission and could be useful tools in malaria control and elimination campaigns.
机译：多种恶性疟原虫抗原抗体的流行率和水平有望作为估计疟疾暴露的工具。在肯尼亚一个传播不稳定的高原地区，我们于2007年8月通过多重细胞珠分析法或ELISA对604名个体进行了检测，并于2008年4月、2009年4月和2010年5月对该队列进行了随访检测，以评估12种红细胞前和血期恶性疟原虫抗原的抗体存在和水平。在所有四个时间点对400人进行了测试。在此期间，唯一一次大规模疟疾发病发生在2009年4月至8月。成人的顶膜抗原1、红细胞结合抗原175、红细胞结合蛋白-2、富含谷氨酸蛋白（GLURP）-R2、裂殖子表面蛋白（MSP）1（19）、MSP-1（42）和肝期抗原-1的抗体患病率在所有时间点都很高（>70%）；GLURP-R0、MSP-3和血小板反应素相关粘附蛋白中度（30-70%）；硒和环子孢子蛋白（CSP）含量较低（<30%）。社区范围内疟疾暴露的变化最好地反映在高免疫原性抗原抗体水平的降低和低免疫原性抗原抗体血清流行率的延长上。在过去的3年里，除了CSP和裂殖子提取物（SE）外，所有抗原的抗体水平都以年龄依赖的方式下降。除CSP和SE外，所有抗原的患病率和抗体水平均随年龄增长而增加。CSP和SE抗体流行率和水平的增加与社区范围疟疾发病率的增加相一致。在缺乏持续传播的情况下，对多种恶性疟原虫抗原的抗体水平降低。对多种红细胞前和血期恶性疟原虫抗原抗体的存在和水平进行评估的多重分析，可能为不稳定传播地区过去和最近的疟疾传播提供最有用的估计，并可能成为疟疾控制和消除运动中有用的工具。

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