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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >No Serologic Evidence of Middle East Respiratory Syndrome Coronavirus Infection among Camel Farmers Exposed to Highly Seropositive Camel Herds: A Household Linked Study, Kenya, 2013
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No Serologic Evidence of Middle East Respiratory Syndrome Coronavirus Infection among Camel Farmers Exposed to Highly Seropositive Camel Herds: A Household Linked Study, Kenya, 2013

机译：没有血清学证据中东呼吸综合征冠状病毒感染骆驼农民暴露于高度血清阳性骆驼群：一项家庭相关的研究，肯尼亚，2013年

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摘要

High seroprevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) among camels has been reported in Kenya and other countries in Africa. To date, the only report of MERS-CoV seropositivity among humans in Kenya is of two livestock keepers with no known contact with camels. We assessed whether persons exposed to seropositive camels at household level had serological evidence of infection. In 2013, 760 human and 879 camel sera were collected from 275 and 85 households respectively in Marsabit County. Data on human and animal demographics and type of contact with camels were collected. Human and camel sera were tested for anti-MERS-CoV IgG using a commercial enzyme-linked immunosorbent assay (ELISA) test. Human samples were confirmed by plaque reduction neutralization test (PRNT). Logistic regression was used to identify factors associated with seropositivity. The median age of persons sampled was 30 years (range: 5-90) and 50% were males. A quarter (197/760) of the participants reported having had contact with camels defined as milking, feeding, watering, slaughtering, or herding. Of the human sera, 18 (2.4%) were positive on ELISA but negative by PRNT. Of the camel sera, 791 (90%) were positive on ELISA. On univariate analysis, higher prevalence was observed in female and older camels over 4 years of age (P < 0.05). On multivariate analysis, only age remained significantly associated with increased odds of seropositivity. Despite high seroprevalence among camels, there was no serological confirmation of MERS-CoV infection among camel pastoralists in Marsabit County. The high seropositivity suggests that MERS-CoV or other closely related virus continues to circulate in camels and highlights ongoing potential for animal-to-human transmission.
机译：据报道，在肯尼亚和非洲其他国家，骆驼中的中东呼吸综合征冠状病毒（MERS-CoV）血清流行率较高。迄今为止，肯尼亚唯一一份关于人类MERS-CoV血清阳性的报告是两名牲畜饲养者与骆驼没有已知接触。我们评估了在家庭层面接触血清阳性骆驼的人是否有感染的血清学证据。2013年，分别从马尔萨比特县275户和85户家庭中采集了760份人类血清和879份骆驼血清。收集了有关人类和动物的人口统计数据，以及与骆驼接触的类型。使用商业酶联免疫吸附试验（ELISA）检测人和骆驼血清中的抗MERS CoV IgG。人类样本经菌斑减少中和试验（PRNT）确认。Logistic回归用于确定与血清阳性相关的因素。抽样人群的平均年龄为30岁（范围：5-90岁），50%为男性。四分之一（197/760）的参与者报告曾接触过定义为挤奶、喂食、浇水、屠宰或放牧的骆驼。在人血清中，18份（2.4%）ELISA呈阳性，而PRNT呈阴性。在骆驼血清中，791份（90%）ELISA呈阳性。单变量分析显示，4岁以上的雌性和老年骆驼的患病率较高（P<0.05）。在多变量分析中，只有年龄与血清阳性率的增加显著相关。尽管骆驼的血清流行率很高，但马萨比特县的骆驼牧民中没有MERS-CoV感染的血清学确认。高血清阳性率表明，MERS-CoV或其他密切相关的病毒继续在骆驼体内传播，并突出了动物对人类传播的持续潜力。

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