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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Epidemiological and Clinical Characteristics of Alveolar Echinococcosis: An Emerging Infectious Disease in Alberta, Canada
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Epidemiological and Clinical Characteristics of Alveolar Echinococcosis: An Emerging Infectious Disease in Alberta, Canada

机译：肺泡脑痛的流行病学与临床特征：加拿大艾伯塔省新出现的传染病

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Human alveolar echinococcosis (AE) is a zoonotic cestode infection which is usually fatal in the absence of treatment. Treatment involves major surgery or indefinite antiparasitic therapy. The incidence is rising in Europe and Asia, with an increased risk observed in immunocompromised individuals. Previously, AE acquisition in North America was extremely rare, except for one remote Alaskan Island. Recent studies have demonstrated a new European-like strain of Echinococcus multilocularis (Em) in wildlife and in human AE in western Canada. We report the experience of all AE patients diagnosed in Alberta. Each was diagnosed by histopathology, serology, and PCR-confirmed by a reference laboratory. Seventeen cases of human AE, aged 19-78 years, nine females, were diagnosed between 2013 and 2020: all definitely or probably acquired in Alberta. Six lived in urban areas, and 14 had kept dogs. In eight, the lesions were found incidentally on abdominal imaging performed for other indications. Six were immunocompromised to varying degrees. Six were first diagnosed at surgery. All have been recommended benzimidazole therapy. One died of surgical complications. Clinicians should be aware of this diagnostic possibility in patients presenting with focal nonmalignant hepatic mass lesions. Greater urbanization of coyotes, the predominant definitive host of Em in Alberta, and growing numbers of immune suppressed individuals in the human population may lead to increasing recognition of AE in North America.
机译：人牙槽棘球蚴病（AE）是一种人畜共患病的绦虫感染，在缺乏治疗的情况下通常是致命的。治疗包括大手术或无限期抗寄生虫治疗。欧洲和亚洲的发病率正在上升，在免疫功能低下的个体中观察到风险增加。此前，除了一个偏远的阿拉斯加岛，AE在北美的收购极其罕见。最近的研究表明，在加拿大西部的野生动物和人类AE中存在一种新的类似欧洲的多房棘球绦虫株（Em）。我们报告了艾伯塔省所有确诊的AE患者的经验。每一个都通过组织病理学、血清学和PCR诊断，并由参考实验室确认。2013年至2020年间，共诊断出17例人类AE，年龄19-78岁，其中9例为女性：全部确诊或可能在阿尔伯塔省获得。其中6人居住在城市地区，14人养过狗。在8例患者中，根据其他适应症进行的腹部成像意外发现了病变。其中6人出现不同程度的免疫功能低下。其中六人是在手术中首次确诊的。所有这些都被推荐为苯并咪唑疗法。其中一人死于手术并发症。临床医生应该意识到，在出现局灶性非恶性肝脏肿块病变的患者中，这种诊断的可能性。在阿尔伯塔省，土狼是Em的主要最终宿主，随着其城市化程度的提高，以及人类群体中免疫抑制个体数量的增加，北美地区对AE的认识可能会增加。

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