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首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >iTBS to Relieve Depression and Executive Dysfunction in Older Adults: An Open Label Study
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iTBS to Relieve Depression and Executive Dysfunction in Older Adults: An Open Label Study

机译：isbs缓解老年人的抑郁和行政功能障碍：开放标签研究

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Background: Executive Function Deficits (EFD) accompany depression and are associated with poor outcomes in older adults. We examined whether Intermittent Theta Burst Stimulation (iTBS) could improve depression with EFD. Methods: Thirteen geriatric patients with depression and EFD were enrolled. Open label iTBS was delivered bilaterally over the dorso-lateral-prefrontal-cortex for four weeks. Results: Montgomery Asberg Depression Scale scores improved significantly from baseline to treatment-end, mean change in score =11.82 points, 95% CI = 8.3, 15.4. The Flanker Inhibitory control and attention test showed significant improvement in executive function from baseline to treatment-end, mean change in score =-7.73, 95% CI (-13.54,-1.92). Side effects included twitching in facial muscles (n = 11), headaches (n = 10) and stimulation discomfort (n = 4). Limitations: Small sample size and lack of a sham comparator. Conclusion: iTBS improved depression with EFD in older adults. Side effects appeared higher than in pwrevious iTBS studies.
机译：背景：执行功能缺陷（EFD）伴随着抑郁症，并与老年人的不良预后相关。我们研究了间歇性θ波爆发刺激（iTBS）是否能改善EFD患者的抑郁症。方法：13例老年抑郁症和EFD患者入选。开放标签iTBS在双侧背外侧前额叶皮质上传递四周。结果：从基线检查到治疗结束，蒙哥马利-阿斯伯格抑郁量表得分显著改善，平均得分变化=11.82分，95%可信区间=8.3,15.4。侧翼抑制控制和注意力测试显示，从基线检查到治疗结束，执行功能显著改善，平均得分变化=-7.73，95%可信区间（-13.54，-1.92）。副作用包括面部肌肉抽搐（n=11）、头痛（n=10）和刺激不适（n=4）。局限性：样本量小，缺乏假对照。结论：iTBS改善了老年人EFD抑郁症状。副作用似乎比以前的iTBS研究更严重。

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