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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Decreased activation and subsyndromal manic symptoms predict lower remission rates in bipolar depression
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Decreased activation and subsyndromal manic symptoms predict lower remission rates in bipolar depression

机译：活化和子系统症状降低预测双极抑郁症降低缓解率

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Objective: Activation encompasses energy and activity and is a central feature of bipolar disorder. However, the impact of activation on treatment response of bipolar depression requires further exploration. The aims of this study were to assess the association of decreased activation and sustained remission in bipolar depression and test for factors that could affect this association. Methods: We assessed participants with Diagnostic and Statistical Manual of Mental Disorders (4th ed) bipolar depression ( n ?=?303) included in a comparative effectiveness study of lithium- and quetiapine-based treatments (the Bipolar CHOICE study). Activation was evaluated using items from the Bipolar Inventory of Symptoms Scale. The selection of these items was based on a dimension of energy and interest symptoms associated with poorer treatment response in major depression. Results: Decreased activation was associated with lower remission rates in the raw analyses and in a logistic regression model adjusted for baseline severity and subsyndromal manic symptoms (odds ratio?=?0.899; p ?=?0.015). The manic features also predicted lower remission (odds ratio?=?0.934; p ?
机译：目的：激活包括能量和活动，是双相情感障碍的核心特征。然而，激活对双相抑郁症治疗反应的影响需要进一步探索。本研究的目的是评估双相抑郁患者激活降低和持续缓解的相关性，并测试可能影响这种相关性的因素。方法：我们评估了《精神障碍诊断与统计手册》（第四版）双相抑郁（n？=303）的参与者，该手册包含在锂和喹硫平治疗的比较有效性研究（双相选择研究）中。使用双相症状量表中的项目评估激活。这些项目的选择是基于能量和兴趣方面的症状，这些症状与抑郁症患者较差的治疗反应有关。结果：在原始分析和逻辑回归模型中，根据基线严重程度和亚综合征躁狂症状调整后，激活减少与较低的缓解率相关（优势比？=？0.899；p？=？0.015）。躁狂特征也预示着较低的缓解率（优势比？=？0.934；p？<？0.001）。两个治疗组的缓解率相似。结论：激活减少和亚综合征躁狂症状预示着双相抑郁症的缓解率降低。具有这些特征的患者可能需要特定的治疗方法，但有必要进行新的研究，以确定能够改善该人群预后的治疗方法。

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