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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Psychotropic medication use in Australia, 2007 to 2015: Changes in annual incidence, prevalence and treatment exposure
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Psychotropic medication use in Australia, 2007 to 2015: Changes in annual incidence, prevalence and treatment exposure

机译：澳大利亚的精神药物用途，2007年至2015年：年发病率，患病率和治疗暴露的变化

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Objective: To examine changes in annual patterns of psychotropic medication use in Australia from 2007 to 2015. Methods: We used a 10% sample of individual-level nationwide dispensing claims for concessional beneficiaries dispensed psychotropic medications (stratified by class, subclass) to investigate annual trends and changes in the incidence and prevalence of use, median annual duration of exposure, proportion of people with single psychotropic dispensing and median defined daily doses per person dispensed each medicine per year. Results: Over the study period, there was a 26.1% decrease in the incidence and a 2.6% increase in the prevalence of all psychotropic medicine use. We observed a decrease in the annual incidence and prevalence of antidepressants (11.6% and 16.8%, respectively) but increases in the median annual duration of exposure (7.4%). Amitriptyline had the highest proportion of single dispensings of all antidepressants throughout the study period (26.5% in 2015) and defined daily doses per person dispensed each medicine per year increased by 20% for antidepressants overall. Benzodiazepine use decreased across all measures over the study period apart from long-term use (exposure for 240 days of the year), which in 2015 was 23.6% of those dispensed a benzodiazepine. We observed a relative increase in the incidence and prevalence of antipsychotic use (14.2% and 26.8%, respectively), and haloperidol had the highest proportion of single dispensings of any antipsychotic throughout the study period (47.5% in 2015). We observed a relative increase in the incidence and prevalence of attention-deficit hyperactivity disorder medication use of 114.0% and 101.8%, respectively, over the study period. Conclusion: Increasing doses and treatment durations of antidepressants warrants further investigation due to concerns about overuse. Single dispensings of amitriptyline and haloperidol may indicate off-label use and long-term use of benzodiazepines remains problematic. Despite increases in attention-deficit hyperactivity disorder medication use, prevalence of use is still much lower than the estimated prevalence of attention-deficit hyperactivity disorder in the adult population. ]]>
机译：目的：研究2007年至2015年澳大利亚精神药物年度使用模式的变化。方法：我们使用10%的全国范围内个体水平的配药申请样本，对特许受益人配药的精神药物（按类别、子类别分层）进行年度趋势和变化调查，包括使用的发生率和流行率、年暴露时间中位数、，使用单一精神药物配药的人群比例，以及每人每年配药的规定日剂量中值。结果：在研究期间，所有精神药物使用的发病率下降了26.1%，患病率上升了2.6%。我们观察到抗抑郁药物的年发病率和患病率下降（分别为11.6%和16.8%），但年暴露时间中位数增加（7.4%）。在整个研究期间，阿米替林在所有抗抑郁药的单次用药中所占比例最高（2015年为26.5%），并且抗抑郁药的规定每人每年每种药物的每日剂量增加了20%。在研究期间，除长期使用（一年中暴露超过240天）外，苯二氮卓的使用在所有测量中都有所减少，2015年，苯二氮卓的使用率为23.6%。我们观察到抗精神病药物使用的发生率和流行率相对增加（分别为14.2%和26.8%），在整个研究期间，氟哌啶醇的单次用药比例最高（2015年为47.5%）。我们观察到，在研究期间，注意缺陷多动障碍药物使用的发生率和患病率分别增加了114.0%和101.8%。结论：由于担心过度使用，增加抗抑郁药的剂量和治疗持续时间值得进一步研究。单次使用阿米替林和氟哌啶醇可能表明非标签使用，长期使用苯二氮卓类药物仍然存在问题。尽管注意缺陷多动障碍药物的使用有所增加，但使用率仍远低于成年人群中注意缺陷多动障碍的估计患病率。]]>

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