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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Characterization of depressed bipolar patients with current suicidal ideation
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Characterization of depressed bipolar patients with current suicidal ideation

机译：抑郁症对双极患者的特征在一起

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Objective: Bipolar disorder is one of the most frequent psychiatric disorders among suicidal patients. A large part of patients with bipolar disorder (30–50%) will attempt suicide. Suicidal ideation being a major risk factor of suicidal act, it is crucial to better characterize patients with suicidal bipolar depression (i.e. depression with current suicidal ideation). The aim of this study was to characterize suicidal bipolar depressed patients in comparison with non-suicidal depressed patients in terms of clinical characteristics, evolution of depression and suicidal ideation course over time, and risk of suicide attempt during follow-up. Methods: Among patients with bipolar disorder recruited from the network of FondaMental expert centres for bipolar disorder between 2009 and 2017, we selected patients with at least mild depression (Montgomery–?sberg Depression Rating Scale total score >11) and without current manic symptomatology (Young Mania Rating Scale total score <7) at baseline ( N ?=?938). Suicidal depression was defined by a baseline score ?2 for item 12 of the Quick Inventory of Depressive Symptomatology–Self Report ( N ?=?271, 28.9%). Non-suicidal depression was defined by a baseline item 12 of the Quick Inventory of Depressive Symptomatology–Self Report score <2 ( N ?=?667, 71.1%). A subsample of about 300 patients (with or without suicidal ideation at baseline) was followed up for 2?years. Results: Baseline clinical features (e.g. depression severity, childhood trauma, global functioning) were more severe in patients with than without suicidal depression. Suicidal patients tended to remain more suicidal throughout the follow-up than patients without suicidal ideation at baseline (3.4-fold higher risk of persistent suicidal ideation at the 2-year visit despite an improvement in depressive symptomatology). Conclusions: Depressed bipolar disorder patients reporting suicidal ideation had more severe clinical features at baseline and were more prone to report persistent suicidal ideation during the follow-up, independently of thymic state. Clinicians should closely monitor this subgroup of patients.
机译：目的：双相情感障碍是自杀患者中最常见的精神障碍之一。大部分双相情感障碍患者（30-50%）会试图自杀。自杀意念是自杀行为的一个主要风险因素，更好地描述自杀性双相抑郁症（即当前有自杀意念的抑郁症）患者的特征至关重要。本研究的目的是在临床特征、抑郁症的演变、自杀意念的过程以及随访期间自杀未遂的风险方面，将自杀性双相抑郁症患者与非自杀性抑郁症患者进行比较。方法：在2009年至2017年间从双相情感障碍基金会专家中心网络招募的双相情感障碍患者中，我们选择了至少患有轻度抑郁症（蒙哥马利–？斯伯格抑郁评定量表总分>11）且在基线检查时无躁狂症状（年轻躁狂评定量表总分<7）的患者（N？=？938）。自杀性抑郁症的定义是基线得分？2.抑郁症状快速清单第12项——自我报告（N？=271，28.9%）。非自杀性抑郁症的定义是抑郁症状快速量表的基线项目12——自我报告得分<2（N？=667，71.1%）。对大约300名患者（基线时有或没有自杀意念）的子样本进行了2年的随访？年。结果：自杀性抑郁症患者的基线临床特征（如抑郁严重程度、儿童创伤、整体功能）比无自杀性抑郁症患者更严重。与基线检查时没有自杀意念的患者相比，在整个随访过程中，有自杀意念的患者倾向于保持更高的自杀意念（尽管抑郁症状有所改善，但2年随访时持续自杀意念的风险高出3.4倍）。结论：报告自杀意念的抑郁症双相情感障碍患者在基线检查时有更严重的临床特征，在随访期间更容易报告持续的自杀意念，与胸腺状态无关。临床医生应该密切关注这一亚组患者。

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