...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Recurring circadian disruption alters circadian clock sensitivity to resetting
【24h】

Recurring circadian disruption alters circadian clock sensitivity to resetting

机译：反复出现的昼夜破坏改变昼夜时钟对重置的敏感性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A single phase advance of the light:dark (LD) cycle can temporarily disrupt synchrony of neural circadian rhythms within the suprachiasmatic nucleus (SCN) and between the SCN and peripheral tissues. Compounding this, modern life can involve repeated disruptive light conditions. To model chronic disruption to the circadian system, we exposed male mice to more than a month of a 20-hr light cycle (LD10:10), which mice typically cannot entrain to. Control animals were housed under LD12:12. We measured locomotor activity and body temperature rhythms in vivo, and rhythms of PER2::LUC bioluminescence in SCN and peripheral tissues ex vivo. Unexpectedly, we discovered strong effects of the time of dissection on circadian phase of PER2::LUC bioluminescent rhythms, which varied across tissues. White adipose tissue was strongly reset by dissection, while thymus phase appeared independent of dissection timing. Prior light exposure impacted the SCN, resulting in strong resetting of SCN phase by dissection for mice housed under LD10:10, and weak phase shifts by time of dissection in SCN from control LD12:12 mice. These findings suggest that exposure to circadian disruption may desynchronize SCN neurons, increasing network sensitivity to perturbations. We propose that tissues with a weakened circadian network, such as the SCN under disruptive light conditions, or with little to no coupling, for example, some peripheral tissues, will show increased resetting effects. In particular, exposure to light at inconsistent circadian times on a recurring weekly basis disrupts circadian rhythms and alters sensitivity of the SCN neural pacemaker to dissection time.
机译：光：暗（LD）周期的单相推进会暂时破坏视交叉上核（SCN）内以及SCN与周围组织之间神经昼夜节律的同步性。除此之外，现代生活还可能涉及反复的破坏性光照条件。为了模拟昼夜节律系统的慢性破坏，我们将雄性小鼠暴露于20小时光周期（LD10:10）中一个多月，而小鼠通常无法进入该周期。对照动物按LD12:12饲养。我们测量了活体内的运动活动和体温节律，以及SCN和离体外周组织中PER2:：LUC生物发光的节律。出乎意料的是，我们发现解剖时间对PER2:：LUC生物发光节律的昼夜节律有强烈影响，这种节律在不同组织中有所不同。白色脂肪组织通过剥离被强烈重置，而胸腺期与剥离时间无关。先前的光照影响了SCN，导致LD10:10下饲养的小鼠通过解剖强烈重置SCN相，而对照LD12:12小鼠的SCN解剖时相移较弱。这些发现表明，暴露于昼夜节律中断可能会使SCN神经元失去同步，增加网络对干扰的敏感性。我们认为，昼夜节律网络减弱的组织，如破坏性光照条件下的SCN，或耦合很少或没有耦合的组织，例如一些外周组织，将显示出增强的重置效应。尤其是，每周反复暴露在不一致的昼夜节律时间下会扰乱昼夜节律，并改变SCN神经起搏器对解剖时间的敏感性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号