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首页> 外文期刊>The European Journal of Neuroscience >Social isolation of adolescent male rats increases anxiety and K~+-induced dopamine release in the nucleus accumbens: Role of CRF-R1
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Social isolation of adolescent male rats increases anxiety and K~+-induced dopamine release in the nucleus accumbens: Role of CRF-R1

机译：青少年雄性大鼠的社会分离会增加焦虑和k〜+诱导的小胺释放在细胞核中：CRF-R1的作用

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摘要

Early life adversity can disrupt development leading to emotional and cognitive disorders. This study investigated the effects of social isolation after weaning on anxiety, body weight and locomotion, and on extracellular dopamine (DA) and glu-tamate (GLU) in the nucleus accumbens (NAc) and their modulation by corticotropin releasing factor receptor 1. On the day of weaning, male rats were housed singly or in groups for 10 consecutive days. Anxiety-like behaviors were assessed by an elevated plus maze (EPM) and an open field test (OF). Neurotransmitter levels were measured by in vivo microdialysis. Single-housed rats spent less time, and entered more, into the closed arms of an EPM than group-housed rats. They also spent less time in the center of an OF, weighed more and showed greater locomotion. In the NAc, no differences in CRF, or in basal extracellular DA or GLU between groups, were observed. A depolarizing stimulus increased DA release in both groups but to higher levels in isolated rats, whereas GLU increased only in single-housed rats. Blocking CRF-R1 receptors with CP-154,526 decreased DA release in single-housed but not in group-housed rats. The corticotropin releasing factor receptor type 1 receptor antagonist also decreased GLU in group-housed animals. These results show that isolating adolescent rats increases anxiety, body weight and ambulation, as well as the sensitivity of dopaminergic neurons to a depolarizing stimulus. This study provides further evidence of the detrimental effects of social isolation during early development and indicates that dysregulation of the CRF system in the NAc may contribute to the pathologies observed.
机译：早期生活中的逆境会破坏发育，导致情绪和认知障碍。本研究探讨了断奶后社会隔离对焦虑、体重和运动的影响，以及对伏隔核（NAc）细胞外多巴胺（DA）和谷氨酸（glu）的影响，以及促肾上腺皮质激素释放因子受体1对其的调节。断奶当天，雄性大鼠被单独或分组饲养连续10天。焦虑样行为通过高架+迷宫（EPM）和野外测试（OF）进行评估。通过体内微透析测定神经递质水平。与集体饲养的大鼠相比，单独饲养的大鼠进入EPM封闭臂的时间更少，进入EPM的时间也更多。他们在一个房间的中心停留的时间更少，体重更重，运动能力更强。在NAc组中，各组之间CRF、基础细胞外DA或GLU无差异。去极化刺激增加了两组大鼠的DA释放，但在离体大鼠中达更高水平，而GLU仅在单室大鼠中增加。用CP-154526阻断CRF-R1受体可减少单室大鼠的DA释放，但在组室大鼠中没有。促肾上腺皮质激素释放因子受体1型受体拮抗剂也降低了群居动物的GLU。这些结果表明，隔离青春期大鼠会增加焦虑、体重和行走能力，以及多巴胺能神经元对去极化刺激的敏感性。这项研究进一步证明了早期发育期间社会隔离的有害影响，并表明NAc中CRF系统的失调可能与观察到的病理学有关。

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