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首页> 外文期刊>The European Journal of Neuroscience >Accelerated brain ageing in sepsis survivors with cognitive long-term impairment
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Accelerated brain ageing in sepsis survivors with cognitive long-term impairment

机译：具有认知长期损伤的败血症幸存者中加速脑老化

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摘要

In the last years, cognitive impairment was emphasized to be a prominent long-term sequelae of sepsis. The level of cognitive impairment is comparable with that in mild cognitive impairment (MCI) patients. Whether sepsis survivors also show a comparable brain atrophy is still unclear. For the analysis of brain atrophy, a novel method named brain age gap estimation (BrainAGE) was used. In this analysis approach, an algorithm identifies age-specific atrophy across the whole brain and calculates a BrainAGE score in years. In case of accelerated brain atrophy, the BrainAGE score is increased in comparison to the healthy age reference group, indicating a difference in estimated chronological age. 20 survivors of severe sepsis (longer than 2 years post sepsis) with persistent cognitive deficits were investigated with a battery of neuropsychological tests. Their MRI images were compared to an age- and sex-matched control group. Sepsis survivors showed a significant higher BrainAGE score of 4.5 years compared to healthy controls. We also found a close relationship between the BrainAGE score and severity of cognitive impairment (a higher BrainAGE score was associated with more severe cognitive impairment). Consequently, sepsis survivors with persistent cognitive impairment showed an accelerated brain ageing, which was closely associated with the severity of cognitive impairment (similar to MCI patients).
机译：在过去的几年里，认知障碍被强调为脓毒症的一个突出的长期后遗症。认知障碍水平与轻度认知障碍（MCI）患者相当。脓毒症幸存者是否也表现出类似的脑萎缩仍不清楚。对于脑萎缩的分析，使用了一种新的方法，名为brain age gap estimation（BrainAGE）。在这种分析方法中，一种算法识别整个大脑的年龄特异性萎缩，并以年为单位计算脑年龄分数。在加速脑萎缩的情况下，与健康年龄对照组相比，BrainAGE得分增加，表明估计的实际年龄存在差异。20名严重脓毒症（脓毒症后2年以上）的存活者持续存在认知缺陷，通过一系列神经心理学测试进行了调查。他们的MRI图像与年龄和性别匹配的对照组进行了比较。与健康对照组相比，脓毒症幸存者的智商得分显著提高，为4.5岁。我们还发现，脑老化评分与认知障碍的严重程度之间存在密切关系（脑老化评分越高，认知障碍越严重）。因此，患有持续性认知障碍的败血症幸存者表现出加速的脑老化，这与认知障碍的严重程度密切相关（与MCI患者相似）。

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