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首页> 外文期刊>The European Journal of Neuroscience >Approaching altered inhibitory control in phenylketonuria: A functional MRI study with a Go-NoGo task in young female adults
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Approaching altered inhibitory control in phenylketonuria: A functional MRI study with a Go-NoGo task in young female adults

机译：接近苯丙酮尿中的改变抑制控制：在年轻女性成年人的Go-Nogo任务中的功能性MRI研究

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Subtle executive function deficits, particularly regarding inhibitory control, have been reported in patients with phenylketonuria (PKU) despite early dietary treatment. Purpose of this study was to assess whether young female adults with PKU exhibit altered neural activity underlying such deficits, particularly in a fronto-parietal cognitive control network (CCN). Behavioural data and functional magnetic resonance imaging (fMRI) data were acquired during a Go-NoGo task in 16 young adult patients with PKU and 17 control subjects. Hypothesis-driven analyses of behavioural and fMRI data in the CCN were supplemented by exploratory whole brain activation analyses. PKU patients exhibited a trend towards higher errors of commission. Patients exhibited marginally increased activation associated with inhibitory control in only one CCN core region (right middle frontal gyrus, p = .043). Whole brain analyses revealed widespread relatively increased activation in adults with PKU in the main task contrast (NoGo > Go). This increased activation was mainly observed outside the CCN and largely overlapped with the default mode network (DMN). In conclusion, only subtle inhibitory control deficits and associated brain activity differences were observed in young adults with PKU. Thus, this work adds to the notion that this particular population seems to be only slightly affected by such cognitive deficits. While there were also only minimal increases when compared to healthy subjects in brain activity in a cognitive control network, we observed more widespread activation increases outside this network. These results support the assumption of DMN dysfunction in PKU.
机译：苯丙酮尿症（PKU）患者尽管接受了早期饮食治疗，但仍存在细微的执行功能缺陷，尤其是在抑制性控制方面。本研究的目的是评估患有PKU的年轻成年女性是否表现出这种缺陷背后的神经活动改变，尤其是在额叶-顶叶认知控制网络（CCN）中。在Go-NoGo任务期间，对16名年轻成年PKU患者和17名对照受试者采集了行为数据和功能磁共振成像（fMRI）数据。对CCN中的行为和功能磁共振成像数据进行假设驱动分析，并辅以探索性全脑激活分析。北大患者表现出更高的委托错误倾向。患者仅在一个CCN核心区域表现出与抑制控制相关的轻微激活增加（右额叶中回，p=0.043）。全脑分析显示，在主要任务对比（NoGo>Go）中，成年PKU患者的激活普遍相对增加。这种增加的激活主要在CCN之外观察到，并且在很大程度上与默认模式网络（DMN）重叠。总之，在患有PKU的年轻人中，仅观察到轻微的抑制性控制缺陷和相关的大脑活动差异。因此，这项工作增加了这样一个概念，即这一特定人群似乎只受到这种认知缺陷的轻微影响。虽然在认知控制网络中，与健康受试者相比，大脑活动的增加幅度也很小，但我们观察到，在该网络之外，更广泛的激活增加。这些结果支持了PKU中DMN功能障碍的假设。

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