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首页> 外文期刊>The European Journal of Neuroscience >Integrin adhesion in brain assembly: From molecular structure to neuropsychiatric disorders
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Integrin adhesion in brain assembly: From molecular structure to neuropsychiatric disorders

机译：整联素粘附在脑组装中：从分子结构到神经精神疾病

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摘要

Integrins are extracellular matrix receptors that mediate biochemical and mechanical bi-directional signals between the extracellular and intracellular environment of a cell thanks to allosteric conformational changes. In the brain, they are found in both neurons and glial cells, where they play essential roles in several aspects of brain development and function, such as cell migration, axon guidance, synaptogenesis, synaptic plasticity and neuro-inflammation. Although there are many successful examples of how regulating integrin adhesion and signaling can be used for therapeutic purposes, for example for halting tumor progression, this is not the case for the brain, where the growing evidence of the importance of integrins for brain pathophysiology has not translated yet into medical applications. Here, we review recent literature showing how alterations in integrin structure, expression and signaling may be involved in the etiology of autism spectrum disorder, epilepsy, schizophrenia, addiction, depression and Alzheimer's disease. We focus on common mechanisms and recurrent signaling pathways, trying to bridge studies on the genetics and molecular structure of integrins with those on synaptic physiology and brain pathology. Further, we discuss integrin-targeting strategies and their potential benefits for therapeutic purposes in neuropsychiatric disorders.
机译：整合素是细胞外基质受体，由于变构构象的改变，它介导细胞内外环境之间的生化和机械双向信号。在大脑中，它们存在于神经元和胶质细胞中，在大脑发育和功能的几个方面发挥着重要作用，如细胞迁移、轴突引导、突触形成、突触可塑性和神经炎症。尽管有许多成功的例子表明，调节整合素粘附和信号传导可以用于治疗目的，例如阻止肿瘤进展，但大脑并非如此，因为越来越多的证据表明整合素对大脑病理生理学的重要性尚未转化为医学应用。在这里，我们回顾了最近的文献，这些文献显示整合素结构、表达和信号的改变可能与自闭症谱系障碍、癫痫、精神分裂症、成瘾、抑郁症和阿尔茨海默病的病因有关。我们专注于常见的机制和循环信号通路，试图将整合素的遗传学和分子结构研究与突触生理学和脑病理学的研究联系起来。此外，我们还讨论了整合素靶向策略及其在神经精神疾病治疗中的潜在益处。

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