Quantitative relations between BOLD responses, cortical energetics and impulse firing across cortical depth

Maxwell R. Bennett; Leslie Farnell; William G. Gibson

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Quantitative relations between BOLD responses, cortical energetics and impulse firing across cortical depth

机译：大胆响应，皮质精力充沛与皮质深度冲击的定量关系

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The blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal arises as a consequence of changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO ) that in turn are modulated by changes in neural activity. Recent advances in imaging have achieved sub-millimetre resolution and allowed investigation of the BOLD response as a function of cortical depth. Here, we adapt our previous theory relating the BOLD signal to neural activity to produce a quantitative model that incorporates venous blood draining between cortical layers. The adjustable inputs to the model are the neural activity and a parameter governing this blood draining. A three-layer version for transient neural inputs and a multi-layer version for constant or tonic neural inputs are able to account for a variety of experimental results, including negative BOLD signals.

机译：血氧水平依赖性（BOLD）功能磁共振成像（fMRI）信号是脑血流量（CBF）和脑氧代谢率（CMRO）变化的结果，而脑血流量和脑氧代谢率反过来又受到神经活动变化的调节。成像技术的最新进展已达到亚毫米分辨率，并允许研究作为皮质深度函数的BOLD反应。在这里，我们调整了我们之前的理论，将BOLD信号与神经活动联系起来，以产生一个定量模型，该模型包含皮质层之间的静脉血液引流。模型的可调输入是神经活动和控制血液排出的参数。瞬态神经输入的三层版本和恒定或紧张神经输入的多层版本能够解释各种实验结果，包括负信号。

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《The European Journal of Neuroscience》 |2021年第1期|共16页
作者
Maxwell R. Bennett; Leslie Farnell; William G. Gibson;
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作者单位

Brain and Mind Research Centre University of Sydney Camperdown NSW Australia;

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正文语种 eng
中图分类神经病学与精神病学;
关键词
cortical layers; haemodynamic model; laminar BOLD response; negative BOLD;

机译：皮质层;血流动力学模型;层状大胆响应;负粗体;

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Quantitative relations between BOLD responses, cortical energetics and impulse firing across cortical depth

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