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首页> 外文期刊>The European Journal of Neuroscience >Activity in orbitofrontal neuronal ensembles reflects inhibitory control
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Activity in orbitofrontal neuronal ensembles reflects inhibitory control

机译：胰胰胰胰胰胰酸的活动反映了抑制控制

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Stopping, or inhibition, is a form of self-control that is a core element of flexible and adaptive behavior. Its neural origins remain unclear. Some views hold that inhibition decisions reflect the aggregation of widespread and diverse pieces of information, including information arising in ostensible core reward regions (i.e., outside the canonical executive system). We recorded activity of single neurons in the orbitofrontal cortex (OFC) of macaques, a region associated with economic decisions, and whose role in inhibition is debated. Subjects performed a classic inhibition task known as the stop signal task. Ensemble decoding analyses reveal a clear firing rate pattern that distinguishes successful from failed inhibition and that begins after the stop signal and before the stop signal reaction time (SSRT). We also found a different and orthogonal ensemble pattern that distinguishes successful from failed stopping before the beginning of the trial. These signals were distinct from, and orthogonal to, value encoding, which was also observed in these neurons. The timing of the early and late signals was, respectively, consistent with the idea that neuronal activity in OFC encodes inhibition both proactively and reactively.
机译：停止或抑制是一种自我控制，是灵活和适应性行为的核心要素。其神经起源尚不清楚。一些观点认为，抑制决定反映了广泛而多样的信息的聚合，包括出现在表面核心奖励区域（即，在规范执行系统之外）的信息。我们记录了猕猴眶额皮质（OFC）中单个神经元的活动，该区域与经济决策有关，其在抑制中的作用存在争议。受试者执行了一项被称为停止信号任务的经典抑制任务。集成解码分析揭示了一个清晰的触发频率模式，该模式区分成功抑制和失败抑制，并在停止信号后和停止信号反应时间（SSRT）之前开始。我们还发现了一种不同的正交整体模式，可以在试验开始前区分成功和失败的停止。这些信号与这些神经元中观察到的值编码不同，并且与值编码正交。早期和晚期信号的时间分别与OFC中的神经元活动对抑制的编码是主动和反应性的这一观点相一致。

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