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首页> 外文期刊>The British Journal of Nutrition >Increased anxiety-like behaviour is an early symptom of vitamin E deficiency that is suppressed by adrenalectomy in rats
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Increased anxiety-like behaviour is an early symptom of vitamin E deficiency that is suppressed by adrenalectomy in rats

机译：焦虑的行为增加是维生素E缺乏的早期症状，其肾上腺切除在大鼠中被抑制

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We previously reported that dietary vitamin E deficiency increased anxiety-like behaviour in rats exposed to social isolation. Here, we performed a detailed investigation of this phenomenon and its underlying mechanism. First, we fed Wistar rats with a vitamin E-free diet for 3 d, 1 week or 2 weeks and found an increase in anxiety-like behaviour after 1 and 2 weeks of vitamin E deficiency based on behavioural indicators. Next, we examined the effect of a control diet (150 mg all-racemic alpha-tocopheryl acetate/kg) on anxiety-like behaviours in rats that received a 4-week vitamin E-free diet. We found that increased anxiety-like behaviour was reversed to control levels after refeeding vitamin E for 7 d but not for 1 or 3 d. Further, anxiety-like behaviour increased or decreased gradually based on the amount of vitamin E intake; however, it had a quicker progression than physical symptoms of vitamin E deficiency. Moreover, rats fed with excess vitamin E (500 mg all-racemic alpha-tocopherol/kg diet) showed less anxiety-like behaviour than control rats, indicating that vitamin E supplementation is effective for preventing anxiety increase under social isolation stress. Since plasma corticosterone levels were higher in vitamin E-deficient rats, we investigated the effect of adrenalectomy on anxiety-like behaviour and found that adrenal hormones played an essential role in the increased anxiety-like behaviour induced by vitamin E deficiency. In conclusion, increased anxiety-like behaviour is a symptom that emerges earlier than physical vitamin E deficiency and is caused by adrenal hormone-dependent mechanisms.
机译：我们之前报道过，膳食维生素E缺乏会增加社交隔离大鼠的焦虑样行为。在这里，我们对这一现象及其潜在机制进行了详细的调查。首先，我们用无维生素E饮食喂养Wistar大鼠3天、1周或2周，发现在维生素E缺乏1周和2周后，行为指标显示焦虑样行为增加。接下来，我们研究了对照饮食（150 mg全外消旋α-生育酚醋酸酯/kg）对接受4周无维生素E饮食的大鼠焦虑样行为的影响。我们发现，在补充维生素E 7天后，焦虑样行为的增加与对照水平相反，但在1或3天内没有。此外，焦虑样行为随着维生素E摄入量的增加而逐渐增加或减少；然而，它比维生素E缺乏的身体症状进展更快。此外，喂食过量维生素E（500 mg全外消旋α-生育酚/kg饮食）的大鼠比对照组大鼠表现出更少的焦虑样行为，表明补充维生素E可有效防止社交隔离应激下的焦虑增加。由于维生素E缺乏大鼠的血浆皮质酮水平较高，我们研究了肾上腺切除术对焦虑样行为的影响，发现肾上腺激素在维生素E缺乏引起的焦虑样行为增加中起着重要作用。总之，焦虑样行为增加是一种比身体维生素E缺乏更早出现的症状，由肾上腺激素依赖机制引起。

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