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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Hyperfamiliarity in Amnestic and Vascular Mild Cognitive Impairment
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Hyperfamiliarity in Amnestic and Vascular Mild Cognitive Impairment

机译：Amnestic和血管轻度认知障碍的Hypertuigierity

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摘要

Objective: Hyperfamiliarity is a phenomenon where new stimuli are perceived as familiar. Previous studies have demonstrated familiarity disorder in mild cognitive impairment (MCI), but mostly from the perspective of a neuropsychological approach, and the exact correlation of MCI aetiologies with the phenomenon remains uncertain. Based on current evidence suggesting a frontal-subcortical pathway contributing to familiarity processing, we hypothesize that individuals with a vascular aetiology of MCI will likely suffer more familiarity deficits. This study aims to examine the real-life hyperfamiliarity symptoms in amnestic versus vascular MCI. Methods: Informants of 11 amnestic and 9 vascular cognitive impairment patients were interviewed about the frequency of hyperfamiliarity symptoms in the previous month. MRI brain images of vascular cognitive impairment patients were analysed as well. Results: Patients with vascular cognitive impairment with no dementia (VCIND) showed a significantly higher frequency of hyperfamiliarity for people but not places or objects. Within VCIND patients, overall basal ganglia hyperintensities, particularly in the putamen, were found to significantly correlate to hyperfamiliarity. Conclusions: Patients with VCIND suffer more real-life hyperfamiliarity during people recognition compared to patients with amnestic mild cognitive impairment (aMCI), despite a comparative global decline in cognitive. This is likely due to impaired memory retrieval and matching processes resulting from subcortical ischaemic lesions.
机译：目的：过度熟悉是一种新刺激被认为是熟悉的现象。以前的研究已经证明轻度认知障碍（MCI）中存在熟悉性障碍，但主要是从神经心理学的角度来看，MCI病因与该现象的确切相关性仍不确定。基于目前的证据表明额叶皮质下通路有助于熟悉性加工，我们假设MCI血管病因的个体可能会遭受更多的熟悉性缺陷。本研究旨在研究遗忘型和血管型MCI患者的现实生活中的过度熟悉症状。方法：对11名健忘症患者和9名血管性认知障碍患者的线人进行访谈，了解他们在前一个月出现过度熟悉症状的频率。还分析了血管性认知障碍患者的MRI脑图像。结果：无痴呆的血管性认知障碍（VCIND）患者对人的超熟悉程度显著较高，但对地点或物体的超熟悉程度不高。在VCIND患者中，发现整体基底节高信号，尤其是壳核高信号与过度熟悉显著相关。结论：与遗忘性轻度认知障碍（aMCI）患者相比，VCIND患者在人的认知过程中遭受了更多的现实生活中的过度熟悉，尽管整体认知能力有所下降。这可能是由于皮质下缺血损伤导致记忆恢复和匹配过程受损所致。

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