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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >The Dysfunction is in the Details: Neurovascular Changes in COVID-19
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The Dysfunction is in the Details: Neurovascular Changes in COVID-19

机译：功能障碍处于详细信息：Covid-19中的神经血管变化

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摘要

Human coronaviruses (HCoVs) can cause a spectrum of disease as indolent as the common cold (described in the 1960s) to severe disease. The dominant phenotype of severe acute respiratory syndrome (SARS) is shared among SARS-CoV-1, Middle East respiratory syndrome (MERS), and now SARS-CoV-2; this latter novel virus shares about 80% of its genomic sequence with SARS-CoV-1. CoVs are enveloped viruses that have single-stranded positive-sense genomes containing approximately 25-32 kilobase pairs as compared to our genome of approximately 3 billion base pairs. In total, seven CoV strains can infect humans including: HCoV-229E (229E), HCoV-OC43 (OC43), SARS-CoV-1, MERS-CoV, HCoV-NL63 (NL63), HCoV-HKU1 (HKU1), and SARS-CoV-2.1 Several of these viruses are neurotropic including HCoV-OC43 (in vitro infection of neuronal cultures, and association with multiple sclerosis in CNS tissue in humans), HCoV-229 E, and there is some evidence that SARS-CoV-1 was present in CSF and brain tissues.2 It is not fully understood if SARS-CoV-2 is directly neurotropic but emerging data suggest a spectrum of endothelial dysfunction and vaculopathy including endothe-litis, and possibly vasculitis. Endothelial cell infection has been described in different organs, including the kidney, liver, heart, and lungs.
机译：人类冠状病毒（HCOV）可以引起一系列疾病，如普通感冒（描述于20世纪60年代）到严重疾病。严重急性呼吸综合征（SARS）的主要表型在SARS-CoV-1、中东呼吸综合征（MERS）和现在的SARS-CoV-2之间共享；后一种新病毒与SARS-CoV-1共有约80%的基因组序列。冠状病毒是一种包膜病毒，其单链正义基因组包含约25-32千碱基对，而我们的基因组约为30亿碱基对。总的来说，七种冠状病毒株可感染人类，包括：HCoV-229E（229E）、HCoV-OC43（OC43）、SARS-CoV-1、MERS-CoV、HCoV-NL63（NL63）、HCoV-HKU1（HKU1）和SARS-CoV-2。1其中一些病毒具有神经营养性，包括HCoV-OC43（神经元培养的体外感染，并与人类中枢神经系统组织的多发性硬化有关）、HCoV-229-E、，有证据表明SARS-CoV-1存在于脑脊液和脑组织中。2目前尚不完全清楚SARS-CoV-2是否直接嗜神经，但新的数据表明存在内皮功能障碍和空泡病，包括内膜炎，可能还有血管炎。内皮细胞感染已在不同器官中被描述，包括肾、肝、心和肺。

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