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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Immunohistochemical Markers in the Diagnosis of Calcifying Pseudoneoplasm of the Neuraxis
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Immunohistochemical Markers in the Diagnosis of Calcifying Pseudoneoplasm of the Neuraxis

机译：免疫组织化学标志物在神经内钙化伪组体诊断中的诊断

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Background: Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare tumor-like lesion with unknown pathogenesis. It is likely under-reported due to diagnostic challenges including the nonspecific radiographic features, lack of diagnostic markers, and often asymptomatic nature of the lesions. Methods: We performed detailed examination of 11 CAPNON specimens diagnosed by histopathology, with the help of electron microscopy and immunohistochemistry. Results: Electron microscopy revealed the presence of fibrillary materials consistent with neurofilaments. In addition to some entrapped axons at the periphery of CAPNONs, we discovered that all specimens stained positive for neurofilament-light (NF-L) within the granular amorphous cores, but not neurofilament-phosphorylated (NF-p). CAPNONs also showed variable infiltration of CD8+ T-cells and a decreased ratio of CD4/CD8+ T-cells, suggesting an immune-mediated process in the pathogenesis of CAPNON. Conclusion: NF-L and CD4/CD8 immunostains may serve as diagnostic markers for CAPNON and shed light on its pathogenesis.
机译：背景：神经轴钙化性假瘤（CAPNON）是一种罕见的肿瘤样病变，其发病机制尚不清楚。由于诊断方面的挑战，包括非特异性放射学特征、缺乏诊断标志物，以及病变的无症状性质，很可能报告不足。方法：在电子显微镜和免疫组织化学的帮助下，我们对11例经组织病理学诊断的卡普农标本进行了详细检查。结果：电子显微镜显示存在与神经丝一致的纤维物质。除了CAPNONs周围的一些被截留的轴突外，我们还发现所有样本在颗粒非晶核内的神经丝光（NF-L）染色呈阳性，但神经丝磷酸化（NF-p）染色不呈阳性。卡普农还表现出CD8+T细胞的可变浸润和CD4/CD8+T细胞比率的降低，表明卡普农的发病机制中存在免疫介导的过程。结论：NF-L和CD4/CD8免疫染色可作为卡普农的诊断标志物，并有助于阐明其发病机制。

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