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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Cortical Spreading Depolarization in Chronic Subdural Hematoma: Bridging the Gap
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Cortical Spreading Depolarization in Chronic Subdural Hematoma: Bridging the Gap

机译：慢性软骨血肿中皮质扩散去极化：桥接间隙

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摘要

Cortical spreading depolarization (CSD) is recognized as a cause of transient neurological symptoms (TNS) in various clinical entities. Although scientific literature has been flourishing in the field of CSD, it remains an underrecognized pathophysiology in clinical practice. The literature evoking CSD in relation to subdural hematoma (SDH) is particularly scarce. Patients with SDH frequently suffer from TNS, most being attributed to seizures despite an atypical semiology, evolution, and therapeutic response. Recent literature has suggested that a significant proportion of those patients' TNS represent the clinical manifestations of underlying CSD. Recently, the term Non-Epileptical Stereoytpical Intermittent Symptoms (NESIS) has been proposed to describe a subgroup of patients presenting with TNS in the context of SDH. Indirect evidence and recent research suggest that the pathophysiology of NESIS could represent the clinical manifestation of CSD. This review should provide a concise yet thorough review of the current state of literature behind the pathophysiology of CSD with a particular focus on recent research and knowledge regarding the presence of CSD in the context of subdural hematoma. Although many questions remain in the evolution of knowledge in this field would likely have significant diagnostic, therapeutic, and prognostic implications.
机译：皮质扩散去极化（CSD）被认为是各种临床实体中短暂神经症状（TNS）的一个原因。尽管科学文献在CSD领域蓬勃发展，但在临床实践中，它仍然是一种未被充分认识的病理生理学。引起CSD与硬膜下血肿（SDH）相关的文献尤其稀少。SDH患者经常患有TNS，尽管有非典型的符号学、进化和治疗反应，但大多数都归因于癫痫发作。最近的文献表明，这些患者的TNS中有很大一部分代表潜在CSD的临床表现。最近，非癫痫性立体视间歇性症状（NESIS）一词被提出用于描述SDH背景下出现TNS的亚组患者。间接证据和最近的研究表明，NESIS的病理生理学可以代表CSD的临床表现。这篇综述应该对CSD病理生理学背后的文献现状进行简要而全面的回顾，特别关注最近关于硬膜下血肿中CSD存在的研究和知识。尽管在这一领域的知识演变过程中仍存在许多问题，但可能会对诊断、治疗和预后产生重大影响。

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