...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Cortical Spreading Depolarizations: Under-Recognized Pathophysiology in Brain Disorders
【24h】

Cortical Spreading Depolarizations: Under-Recognized Pathophysiology in Brain Disorders

机译：皮质扩散去极化：脑疾病中公认的病理生理学

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this issue, Levesque et al. provide a comprehensive review on the topic of nonepileptical stereotyped intermittent symptoms (NESIS) in various forms of brain injury and the transient neurologic symptoms (TNS) observed in chronic subdural hematoma (cSDH) patients1. For those who manage cSDH patients, this is a vexing clinical problem which is often refractory to typical anticonvulsants and electroencephalogram (EEG) often fails to show evidence of epileptiform activity, just slowing and electrical attenuation. In cSDH, neuroimaging may not show structural changes to warrant surgical intervention, yet symptoms are often recurrent and stereotyped despite one or more anticon-vulsant drugs. Symptoms are often distressing to patients, nurses, and clinicians since they remain of unknown etiology. The term NESIS is an important, potentially unifying terminology that has diagnostic and prognostic implications2 . In a cohort of 84 patients hospitalized for treatment of cSDH, 26% experienced TNS. Of these, 59% scored positive for NESIS. Remarkably, mortality rate was 0% in the NESIS group compared to 33% in the nonNESIS group, the latter mainly considered to have seizures. Hence in the context of cSDHs, seizures are a bad prognostic sign.
机译：在本期中，Levesque等人对各种形式脑损伤中的非癫痫刻板印象间歇性症状（NEIS）以及慢性硬膜下血肿（cSDH）患者中观察到的短暂神经症状（TNS）进行了全面综述1。对于那些管理cSDH患者的人来说，这是一个令人烦恼的临床问题，通常对典型的抗惊厥药不起作用，脑电图（EEG）往往无法显示癫痫样活动的证据，只是减慢和电衰减。在cSDH中，神经影像学可能无法显示结构变化以保证手术干预，但尽管使用了一种或多种抗排卵药物，但症状通常是反复出现的和定型的。这些症状通常令患者、护士和临床医生感到痛苦，因为它们的病因仍然未知。NESIS一词是一个重要的、潜在的统一术语，具有诊断和预后意义2。在84名因cSDH住院治疗的患者队列中，26%的患者出现TNS。其中59%的人对NESIS评分为阳性。值得注意的是，NESIS组的死亡率为0%，而非NESIS组的死亡率为33%，后者主要被认为是癫痫发作。因此，在CSDH的情况下，癫痫发作是一个不良的预后迹象。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号