Prospective Study Demonstrates Utility of EP-QuIC in Creutzfeldt-Jakob Disease Diagnoses

Sharon L. R. Simon; Anne Peterson; Clark Phillipson; Jonathan M. Walker; Meika Richmond; Gerard H. Jansen

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Prospective Study Demonstrates Utility of EP-QuIC in Creutzfeldt-Jakob Disease Diagnoses

机译：前瞻性研究证明了克雷兹菲尔特 - 雅各布疾病诊断的EP-Quic的效用

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Prospectively acquired Canadian cerebrospinal fluid samples were used to assess the performance characteristics of three ante-mortem tests commonly used to support diagnoses of Creutzfeldt-Jakob disease. The utility of the end-point quaking-induced conversion assay as a test for Creutzfeldt-Jakob disease diagnoses was compared to that of immunoassays designed to detect increased amounts of the surrogate markers 14-3-3γ and hTau. The positive predictive values of the end-point quaking-induced conversion, 14-3-3γ, and hTau tests conducted at the Prion Diseases Section of the Public Health Agency of Canada were 96%, 68%, and 66%, respectively.

机译：前瞻性采集的加拿大脑脊液样本用于评估三种常用于支持克雅氏病诊断的宰前测试的性能特征。将终点震动诱导转化试验作为克雅氏病诊断试验的效用与免疫试验进行比较，免疫试验旨在检测替代标记物14-3-3γ和hTau的增加量。在加拿大公共卫生署朊病毒疾病科进行的终点震颤诱发转化试验、14-3-3γ试验和hTau试验的阳性预测值分别为96%、68%和66%。

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来源
《The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques》 |2021年第1期|共3页
作者
Sharon L. R. Simon; Anne Peterson; Clark Phillipson; Jonathan M. Walker; Meika Richmond; Gerard H. Jansen;
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作者单位

From the Prion Diseases Section National Microbiology Laboratory Public Health Agency of Canada;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Creutzfeldt-Jakob disease; Prion; RT-QuIC; EP-QuIC;

机译：Creutzfeldt-Jakob病;朊病毒;RT-Quic;EP-QUIC;

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Prospective Study Demonstrates Utility of EP-QuIC in Creutzfeldt-Jakob Disease Diagnoses

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