Cystic fibrosis transmembrane conductance regulator (CFTR) regulates embryonic organizer formation during zebrafish early embryogenesis

Liu Yanyan; Lin Ziyuan; Sun Huaqin

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Cystic fibrosis transmembrane conductance regulator (CFTR) regulates embryonic organizer formation during zebrafish early embryogenesis

机译：囊性纤维化跨膜电导调节剂（CFTR）调节斑马鱼早期胚胎发生期间的胚胎组织者形成

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Cystic fibrosis (CF) is associated with the manifestation of a number of medical conditions throughout the body. This prompted us to investigate the etiology of CF from the viewpoint of the embryonic organizer, which is responsible for steering the movement of surrounding cells into specific organs and tissues. In our previous work, we found that a cftr mutant had decreased nuclear beta-catenin levels in the early embryo at 5 hours post-fertilization (hpf), when the organizer forms. It is known that nuclear beta-catenin signaling is essential for the induction of the dorsal organizer. Therefore, we explored the role of cftr in the formation of the embryonic organizer in this work. Indeed, the expression of organizer and germ layer markers was significantly affected in cftr mutant embryos dependent on Wnt/beta-catenin signaling. Furthermore, quantitative proteome analysis revealed that the cftr mutant induced significant alteration in the expression of proteins related to many critical biological processes, cellular components, molecular functions, and signaling pathways, except for the Wnt/beta-catenin pathway. These findings demonstrate the function of cftr in embryonic organizer formation and provide an explanation for why many abnormalities occur in the bodies of CF patients.

机译：囊性纤维化（CF）与全身许多疾病的表现有关。这促使我们从胚胎组织者的角度研究CF的病因，胚胎组织者负责引导周围细胞进入特定器官和组织。在我们之前的研究中，我们发现一个cftr突变体在受精后5小时（hpf）早期胚胎中的核β-连环蛋白水平降低，此时组织形成。众所周知，核β-连环蛋白信号对背侧组织者的诱导至关重要。因此，我们在这项工作中探索了cftr在胚胎组织者形成中的作用。事实上，在依赖Wnt/beta-catenin信号的cftr突变胚胎中，组织者和生殖层标记物的表达受到显著影响。此外，定量蛋白质组分析显示，除了Wnt/beta-catenin途径外，cftr突变体诱导了与许多关键生物过程、细胞成分、分子功能和信号通路相关的蛋白质表达的显著改变。这些发现证明了cftr在胚胎形成中的功能，并解释了为什么CF患者体内会出现许多异常。

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来源
《The international journal of developmental biology》 |2020年第9期|共5页
作者
Liu Yanyan; Lin Ziyuan; Sun Huaqin;
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作者单位

Sichuan Univ West China Second Univ Hosp Dept Obstet &

Gynecol Prenatal Diag Ctr Chengdu Peoples R China;

Sichuan Univ West China Second Univ Hosp Minist Educ Dept Pediat SCU CUHK Joint Lab Reprod Med Key Lab Birth Defec Chengdu 610041 Peoples R China;

Sichuan Univ West China Second Univ Hosp Minist Educ Dept Pediat SCU CUHK Joint Lab Reprod Med Key Lab Birth Defec Chengdu 610041 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类普通胚胎学;
关键词
CFTR; organizer; early embryogenesis;

机译：CFTR;组织者;早期胚胎发生;

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1. The classification of ATP-binding cassette subfamily A member 3 mutations using the cystic fibrosis transmembrane conductance regulator classification system [J] . Laura Denman, Lael M. Yonker, Thomas Bernard Kinane 儿科学（英文） . 2018,第001期
2. Acquired cystic fibrosis transmembrane conductance regulator dysfunction [J] . Catherine Banks, Laura Freeman, Do Yeon Cho, 世界耳鼻咽喉头颈外科杂志（英文） . 2018,第003期
3. The classification of ATP-binding cassette subfamily A member 3 mutations using the cystic fibrosis transmembrane conductance regulator classification system [J] . Laura Denman, Lael M. Yonker, Thomas Bernard Kinane 儿科学研究（英文） . 2018,第001期
4. ERp29 Regulates ΔF508 and Wild-type Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Trafficking to the Plasma Membrane in Cystic Fibrosis (CF) and Non-CF Epithelial Cells [J] . Laurence Suaud, Katelyn Miller, Lora Alvey, The Journal of biological chemistry . 2011,第24期

机译：ERP29调节ΔF508和野生型囊性纤维化跨膜电导调节器（CFTR）在囊性纤维化（CF）和非CF上皮细胞中的血浆膜上
5. Cystic fibrosis transmembrane conductance regulator-modifying medications: The future of cystic fibrosis treatment [Los medicamentos modificadores de la regulación de la conducción de la fibrosis quística a través de la membrana (CFTR): El futuro del tratamiento de la fibrosis quística] [J] . PettitR.S. The annals of pharmacotherapy . 2012,第7a8期

机译：囊性纤维化跨膜电导调节剂修饰药物：囊性纤维化治疗的未来。
6. The Formation of the cAMP/Protein Kinase A-dependent Annexin 2–S100A10 Complex with Cystic Fibrosis Conductance Regulator Protein (CFTR) Regulates CFTR Channel Function [J] . Lee A. Borthwick, Jean Mcgaw, Gregory Conner, Molecular biology of the cell . 2007,第9期

机译：cAMP /蛋白激酶A依赖性膜联蛋白2-S100A10复合物与囊性纤维化电导调节蛋白（CFTR）的形成调节CFTR通道功能
7. Quantitative mass spectrometry for analysis of membrane expression of cystic fibrosis transmembrane conductance regulator (CFTR) [C] . Alexis A. Ramos, Bonita A. Coutermarsh, Pamela C. Diego, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：囊性纤维化跨膜电导调节器（CFTR）膜表达分析的定量质谱
8. CFTR-associated ligand (CAL)-dependent post-Golgi trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) is modulated by insulin-like growth factor 1 (IGF-1). [D] . Lee, Ha Won. 2012

机译：囊性纤维化跨膜电导调节剂（CFTR）的CFTR相关配体（CAL）依赖性高尔基体运输受到胰岛素样生长因子1（IGF-1）的调节。
9. MAST205 Competes with Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-associated Ligand for Binding to CFTR to Regulate CFTR-mediated Fluid Transport [O] . Aixia Ren, Weiqiang Zhang, Sunitha Yarlagadda, 2013

机译：MAST205与囊性纤维化跨膜电导调节剂（CFTR）相关配体竞争与CFTR绑定以调节CFTR介导的液体运输。
10. MAST205 Competes with Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-associated Ligand for Binding to CFTR to Regulate CFTR-mediated Fluid Transport [O] . Aixia Ren, Weiqiang Zhang, Sunitha Yarlagadda, 2013

机译：MAST205竞争囊性纤维化跨膜电导调节剂（CFTR） - 分配配体，用于与CFTR结合调节CFTR介导的流体运输

Cystic fibrosis transmembrane conductance regulator (CFTR) regulates embryonic organizer formation during zebrafish early embryogenesis

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