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Brief interventions to prevent excessive alcohol use in adolescents at low-risk presenting to Emergency Departments: Three-arm, randomised trial of effectiveness and cost-effectiveness

机译:简短的干预措施,以防止在急诊部门的低风险下的青少年过度饮酒:三臂,随机试验的有效性和成本效益

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Background: Alcohol consumption and related harm increase rapidly from the age of 12 years. We evaluated whether alcohol screening and brief intervention is effective and cost-effective in delaying hazardous or harmful drinking amongst low-risk or abstaining adolescents attending Emergency Departments (EDs). Methods: This ten-centre, three-arm, parallel-group, single-blind, pragmatic, individually randomised trial screened ED attenders aged between 14 and 17 years for alcohol consumption. We sampled at random one third of those scoring at most 2 on AUDIT-C who had access to the internet and, if aged under 16, were Gillick competent or had informed consent from parent or guardian. We randomised them between: screening only (control intervention); one session of face-to-face Personalised Feedback and Brief Advice (PFBA); and PFBA plus an electronic brief intervention (eBI) on smartphone or web. We conducted follow-up after six and 12 months. The principal outcomes were alcohol consumed over the 3 months before 12-month follow up, measured by AUDIT-C; and quality-adjusted life-years. Findings: Between October 2014 and May 2015, we approached 5,016 eligible patients of whom 3,326 consented to be screened and participate in the trial; 2,571 of these were low-risk drinkers or abstainers, consuming an average 0.14 units per week. We randomised: 304 to screening only; 285 to PFBA; and 294 to PFBA and eBI. We found no significant difference between groups, notably in weekly alcohol consumption: those receiving screening only drank 0.10 units (95% confidence interval 0.05 to 0.18); PFBA 0.12 (0.06 to 0.21); PFBA and eBI 0.10 (0.05 to 0.19). Interpretation: While drinking levels remained low in this population, this trial found no evidence that PFBA with or without eBI was more effective than screening alone in reducing or delaying alcohol consumption.
机译:背景:从12岁开始,酒精消费和相关危害迅速增加。我们评估了酒精筛查和短期干预是否有效,是否具有成本效益,可以在急诊科(EDs)的低风险或戒酒青少年中延迟危险或有害的饮酒。方法:这项十中心、三臂、平行组、单盲、务实、个体随机的试验对14至17岁的未住院患者进行了饮酒筛查。我们随机抽样了三分之一在AUDIT-C上得分最多为2的人,这些人可以上网,如果年龄在16岁以下,他们是Gillick胜任的,或者得到了父母或监护人的知情同意。我们将他们随机分为两组:仅筛查(对照干预);一次面对面的个性化反馈和简短建议(PFBA);PFBA加上智能手机或网络上的电子简短干预(eBI)。我们在6个月和12个月后进行了随访。主要结果是在12个月随访前的3个月内饮酒,通过AUDIT-C测量;以及经过质量调整的生命年数。调查结果:2014年10月至2015年5月,我们接触了5016名合格患者,其中3326人同意接受筛查并参与试验;其中2571人是低风险饮酒者或戒酒者,平均每周消费0.14个单位。我们随机分组:304例仅用于筛查;285至PFBA;PFBA和eBI分别为294和294。我们发现两组之间没有显著差异,尤其是在每周饮酒量方面:接受筛查的人只喝0.10单位(95%置信区间0.05至0.18);PFBA 0.12(0.06至0.21);PFBA和息税前利润为0.10(0.05至0.19)。解释:虽然该人群的饮酒水平仍然较低,但该试验未发现证据表明,在减少或延迟饮酒方面,PFBA加或不加eBI比单独筛查更有效。

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