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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >The expression of miRNA encoded by C19MC and miR-371-3 strongly varies among individual placentas but does not differ between spontaneous and induced abortions
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The expression of miRNA encoded by C19MC and miR-371-3 strongly varies among individual placentas but does not differ between spontaneous and induced abortions

机译：C19MC和MIR-371-3编码的miRNA的表达在个体胎盘之间强烈变化，但自发性和诱导的堕胎之间没有差异

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摘要

miRNAs of the largest human miRNA gene cluster at all, i.e., C19MC, are almost exclusively expressed in the placenta. Nevertheless, only little is known about the interindividual variation of their expression and even about possible influence of gestational age, conflicting data is reported as well as for miRNAs of the much smaller miR-371-3 cluster. Our present study aims at the analyses of the expression of miRNAs from both clusters at different times of pregnancy, possible differences between placenta samples obtained from spontaneous or induced abortions in the first trimester, and the possible variation of miRNA expression at different sites within same placentas. miR-371a-3p, miR-372-3p, miR-373-3p, miR-517a-3p, and miR-520c-3p were quantified in 85 samples and miR-371a-3p was quantified in maternal serum samples taken immediately before delivery. While for miRNA-517a-3p and miR-520c-3p the expression increased with increasing gestational age, the present study revealed strong interindividual differences in the expression of miR-371-3 in full-term placental tissue as well as for miRNAs of the C19MC cluster, where the levels differed to a much lesser extent than for the former microRNAs. Also, strong interindividual differences were noted between the serum samples but differences related to the site of the placenta where the sample has been taken from were excluded. For neither of the data from placental tissue, the study revealed differences between the spontaneous and induced abortion group. Thus, the differences do not in general seem to be related to first trimester abortion. It remains to be elucidated whether or not they affect other prenatal processes.
机译：最大的人类miRNA基因簇，即C19MC的miRNA，几乎只在胎盘中表达。然而，关于其表达的个体间差异，甚至关于胎龄的可能影响，我们知之甚少，关于小得多的miR-371-3簇的miRNA，也有相互矛盾的数据报道。我们目前的研究旨在分析两个簇在妊娠不同时间的miRNA表达，妊娠早期自然流产或人工流产的胎盘样本之间可能存在的差异，以及同一胎盘内不同部位miRNA表达的可能变化。在85份样本中对miR-371a-3p、miR-372-3p、miR-373-3p、miR-517a-3p和miR-520c-3p进行定量，并在分娩前立即采集的母亲血清样本中对miR-371a-3p进行定量。虽然miRNA-517a-3p和miR-520c-3p的表达随着胎龄的增加而增加，但本研究显示，在足月胎盘组织中以及C19MC簇的miRNA中，miR-371-3的表达存在强烈的个体间差异，其水平差异远小于之前的microRNA。此外，血清样本之间存在明显的个体差异，但不包括与胎盘部位相关的差异。对于这两个来自胎盘组织的数据，该研究揭示了自然流产组和人工流产组之间的差异。因此，这些差异总体上似乎与孕早期流产无关。它们是否会影响其他产前过程还有待阐明。

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