Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Abdelkader Mohamed S. A.; Philippon Thomas; Asenjo Juan A.; Bull Alan T.; Goodfellow Michael; Ebel Rainer; Jaspars Marcel; Rateb Mostafa E.

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Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

机译：asenjonamides a-c，从Streptomyces分离的抗菌代谢物，来自瘦身菌菌株42.f，来自极端的干旱的阿哈马沙漠土壤

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Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive beta-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-beta-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

机译：asenjonii链霉菌菌株KNN 42培养液提取物的生物引导分级。从智利北部极端超干旱的阿塔卡马沙漠土壤中回收的f导致分离出三种新的生物活性β-二酮；除已知的N-（2-（1H-吲哚-3-基）-2-氧乙基）乙酰胺（4）外，阿诺酰胺A-C（1-3），一系列具有生物活性的酰化4-氨基庚基-β-N-糖苷；蜘蛛霉素A-E（5-9）和七种已知的二酮哌嗪（10-16）。所有分离的化合物都通过HRESIMS和NMR分析进行了表征，并测试了它们对一组细菌的抗菌效果。

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来源
《The Journal of Antibiotics: An International Journal》 |2018年第4期|共7页
作者
Abdelkader Mohamed S. A.; Philippon Thomas; Asenjo Juan A.; Bull Alan T.; Goodfellow Michael; Ebel Rainer; Jaspars Marcel; Rateb Mostafa E.;
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作者单位

Sohag Univ Fac Pharm Dept Pharmacognosy Sohag 82524 Egypt;

Univ Aberdeen Dept Chem Marine Biodiscovery Ctr Aberdeen AB24 3UE Scotland;

Univ Chile Ctr Biotechnol &

Bioengn CeBiB Dept Chem Engn &

Biotechnol Beauchef 851 Santiago;

Univ Kent Sch Biosci Canterbury CT2 7NJ Kent England;

Newcastle Univ Sch Biol Ridley Bldg Newcastle Upon Tyne NE1 7RU Tyne &

Wear England;

Univ Aberdeen Dept Chem Marine Biodiscovery Ctr Aberdeen AB24 3UE Scotland;

Univ Aberdeen Dept Chem Marine Biodiscovery Ctr Aberdeen AB24 3UE Scotland;

Univ West Scotland Sch Sci &

Sport Paisley PA1 2BE Renfrew Scotland;

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正文语种 eng
中图分类药学;
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1. Identification and Evaluation of UV-Tolerant Streptomyces araujoniae Strain Isolated from Tibet Plateau Soil as Biocontrol Agent Against Rice Blast [J] . LIU Lianmeng, ZHAO Yuan, LU Jiying, 水稻科学（英文版） . 2020,第005期
2. An Arthrobacter strain isolated from desert soils in the region of Shule River (China) can convert cellulose to potential biofuels [J] . Constantine Uwaremwe, ShiWeng Li, XiMing Chen, 寒旱区科学：英文版 . 2017,第002期
3. An Arthrobacter strain isolated from desert soils in the region of Shule River (China) can convert cellulose to potential biofuels [J] . Constantine Uwaremwe, ShiWeng Li, XiMing Chen, 寒旱区科学（英文版） . 2017,第002期
4. Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil [J] . Abdelkader Mohamed S. A., Philippon Thomas, Asenjo Juan A., The Journal of Antibiotics: An International Journal . 2018,第4期

机译：asenjonamides a-c，从Streptomyces分离的抗菌代谢物，来自瘦身菌菌株42.f，来自极端的干旱的阿哈马沙漠土壤
5. Streptomyces asenjonii sp nov., isolated from hyper-arid Atacama Desert soils and emended description of Streptomyces viridosporus Pridham et al. 1958 [J] . Goodfellow Michael, Busarakam Kanungnid, Idris Hamidah, Antonie van Leeuwenhoek: Journal of Microbiology and serology . 2017,第9期

机译：从Hyper-Atid Atacama沙漠土壤中分离出来的Streptomyces Asenjonii Sp和Cheredomyces Vidiscosporus Pridham等人的化为。 1958年
6. Streptomyces deserti sp. nov., isolated from hyper-arid Atacama Desert soil [J] . Rakesh Santhanam, Chinyere K. Okoro, Xiaoying Rong, Antonie van Leeuwenhoek . 2012,第3期

机译：沙漠链霉菌十一月，从超干旱阿塔卡马沙漠土壤中分离
7. Structure characteristics of antibacterial compound isolated from the secondary metabolites from Streptomyces roseogilvus var. marinus [C] . Liu Yun, Lin Qinxiong The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议）论文集 . 2009

机译：从玫瑰链霉菌次级代谢产物中分离的抗菌化合物的结构特征。马里纳斯
8. The mechanism and timescales of soil formation in the hyper-arid atacama desert, Chile. [D] . Wang, Fan. 2013

机译：智利超干旱阿塔卡马沙漠土壤形成的机理和时标。
9. Streptomyces asenjonii sp. nov. isolated from hyper-arid Atacama Desert soils and emended description of Streptomyces viridosporus Pridham et al. 1958 [O] . Michael Goodfellow, Kanungnid Busarakam, Hamidah Idris, -1

机译：Asenjonii链霉菌11月从高干旱的阿塔卡马沙漠土壤中分离出来并修改了链霉菌viridosporus Pridham等的描述。 1958年
10. Streptomyces asenjonii sp. nov., isolated from hyper-arid Atacama Desert soils and emended description of Streptomyces viridosporus Pridham et al. 1958 [O] . Goodfellow, Michael, Busarakam, Kanungnid, Idris, Hamidah, 2017

机译：Asenjonii链霉菌11月，从高干旱的阿塔卡马沙漠土壤中分离，并修改了链霉菌viridosporus Pridham等的描述。 1958年
11. Systematic description and key to streptomyces isolants from Chile-Atacama Desert, Hawaii, and Oregon soils [R] . Bollen, W. B., Nishikawa, S. 1968

机译：系统描述和来自智利 - 阿塔卡马沙漠，夏威夷和俄勒冈土壤的链霉菌分离物的关键

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Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

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