Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway

Shimizu Yohei; Ogasawara Yasushi; Matsumoto Atsuko; Dairi Tohru

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Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway

机译：aplasmOcycin和硼霉素是无岩途径的特异性抑制剂

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We searched for specific inhibitors of the futalosine pathway, non-canonical pathway of menaquinone biosynthesis operating in Helicobacter pylori, from metabolites produced by actinomycetes. Aplasmomycin, a boron-containing macrodiolide, was isolated from Streptomyces sp. K15-0223 as a specific inhibitor of the futalosine pathway. We also showed boromycin, an analog of aplasmomycin, had similar activity.

机译：我们从放线菌产生的代谢物中寻找了在幽门螺杆菌中运作的非典型甲萘醌生物合成途径——双硫氰酸途径的特异性抑制剂。Aplasmycin是从链霉菌K15-0223中分离出来的一种含硼大二醇，是一种特异性的富托糖途径抑制剂。我们还发现博罗霉素，一种类似于再障霉素的物质，也有类似的活性。

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《The Journal of Antibiotics: An International Journal》 |2018年第11期|共3页
作者
Shimizu Yohei; Ogasawara Yasushi; Matsumoto Atsuko; Dairi Tohru;
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作者单位

Hokkaido Univ Grad Sch Engn Sapporo Hokkaido 0608628 Japan;

Hokkaido Univ Grad Sch Engn Sapporo Hokkaido 0608628 Japan;

Kitasato Univ Grad Sch Infect Control Sci Minato Ku Tokyo 1088641 Japan;

Hokkaido Univ Grad Sch Engn Sapporo Hokkaido 0608628 Japan;

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正文语种 eng
中图分类药学;
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机译：aplasmOcycin和硼霉素是无岩途径的特异性抑制剂
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Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway

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