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首页> 外文期刊>The Journal of Antibiotics: An International Journal >OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctum
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OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctum

机译：OSMAC方法导致来自Fusarium TriCinctinum的新Fusarielin代谢物

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摘要

Using the OSMAC (One Strain MAny Compounds) approach, the fungal endophyte Fusarium tricinctum was cultivated on fruit and vegetable juice-supplemented solid rice media. This led to an up to 80-fold increase in the accumulation of the new natural product fusarielin J (1), as well as to the induction of two new natural products fusarielin K (2) and fusarielin L (3) and the known derivatives fusarielins A (4) and B (5). Compounds 2-5 were not detected when the fungus was grown on rice media lacking either fruit or vegetable juice. The highest increase in the accumulation of compound 1 was observed in the presence of apple and carrot juice, whereas the stimulating effect was weaker for banana juice. Compound 1 exhibited cytotoxicity against the human ovarian cancer cell line A2780, with an IC50 value of 12.5 mu m.
机译：采用OSMAC（一株多化合物）方法，在添加果蔬汁的固体水稻培养基上培养真菌内生真菌三尖镰刀菌。这导致新的天然产物镰刀菌素J（1）的积累增加了80倍，并诱导了两种新的天然产物镰刀菌素K（2）和镰刀菌素L（3）以及已知的衍生物镰刀菌素A（4）和B（5）。当真菌生长在缺乏水果或蔬菜汁的水稻培养基上时，没有检测到化合物2-5。在苹果汁和胡萝卜汁中，化合物1的积累量最高，而香蕉汁的刺激作用较弱。化合物1对人卵巢癌细胞系A2780具有细胞毒性，IC50值为12.5μm。

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