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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Fradiamine A, a new siderophore from the deep- sea actinomycete Streptomyces fradiae MM456M-mF7
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Fradiamine A, a new siderophore from the deep- sea actinomycete Streptomyces fradiae MM456M-mF7

机译：Fradiamine A，来自Deef-Sea辐射瘤的新剑道Streptomyces Fradiae MM456M-MF7

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摘要

New bioactive substances were identified from several marine actinomycetes strains by LC-HRESI-MS based non-targeted metabolomics. A new siderophore and its derivative, named fradiamines A and B, were isolated from the extract of the deep-sea actinomycetes Streptomyces fradiae MM456M-mF7 by Diaion CHP-20P, Sephadex LH-20 column chromatography and HPLC. Fradiamine A was a new compound, but fradiamine B was previously patented as a sweetness enhancer. Their structures were determined by NMR and LC-HRESI-MS/MS analysis. Fradiamines A and B contained two alkyl amines asymmetrically bonded to citrate, a type of structure derived from actinomycetes and other bacteria and rarely observed in siderophores. Fradiamines A and B showed moderate antibiotic activity against Clostridium difficile with IC50 values of 32 and 8 mu g ml(-1), respectively.
机译：基于LC-HRESI-MS的非靶向代谢组学从几种海洋放线菌菌株中鉴定出新的生物活性物质。通过二离子CHP-20P、Sephadex LH-20柱层析和HPLC从深海放线菌fradiae Streptomyces MM456M-mF7的提取物中分离出一种新的铁载体及其衍生物fradiamines A和B。Fradiamine A是一种新化合物，但Fradiamine B之前作为甜味剂获得了专利。通过核磁共振和LC-HRESI-MS/MS分析确定了它们的结构。Fradiamines A和B含有两种不对称结合到柠檬酸盐上的烷基胺，柠檬酸盐是一种从放线菌和其他细菌中衍生出来的结构，很少在铁载体中观察到。Fradiamines A和B对艰难梭菌表现出中等的抗生素活性，IC50值分别为32和8μg ml（-1）。

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